Literature DB >> 25870002

[Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics].

S O Decker1, M Wortmann, B H Siegler, A Ulrich, S Hofer, T Brenner.   

Abstract

Metformin-induced lactic acidosis is a rare but severe disease for the individual patients. A case of a 64-year-old patient with diabetes mellitus type 2 suffering from this disease is presented where metformin accumulation was caused by prerenal acute kidney failure. The clinical evaluation up to the final diagnosis, the pathophysiology and the appropriate therapy are presented in detail. Additionally, the current guidelines regarding the perioperative management of metformin administration are summarized. The case described aims to direct attention to the rare but, nevertheless, severe symptoms of metformin-induced lactic acidosis.

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Year:  2015        PMID: 25870002     DOI: 10.1007/s00101-015-0017-7

Source DB:  PubMed          Journal:  Anaesthesist        ISSN: 0003-2417            Impact factor:   1.041


  17 in total

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Journal:  Anaesthesist       Date:  2002-06       Impact factor: 1.041

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Authors:  Dennis R Cryer; Savian P Nicholas; David H Henry; Donna J Mills; Bruce V Stadel
Journal:  Diabetes Care       Date:  2005-03       Impact factor: 19.112

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Journal:  Cochrane Database Syst Rev       Date:  2010-01-20

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Authors:  Barbara Brunmair; Katrin Staniek; Florian Gras; Nicole Scharf; Aleksandra Althaym; Renate Clara; Michael Roden; Erich Gnaiger; Hans Nohl; Werner Waldhäusl; Clemens Fürnsinn
Journal:  Diabetes       Date:  2004-04       Impact factor: 9.461

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Authors:  Kasia J Lipska; Clifford J Bailey; Silvio E Inzucchi
Journal:  Diabetes Care       Date:  2011-06       Impact factor: 19.112

10.  Outcome of severe lactic acidosis associated with metformin accumulation.

Authors:  Sigrun Friesecke; Peter Abel; Markus Roser; Stephan B Felix; Soeren Runge
Journal:  Crit Care       Date:  2010-12-20       Impact factor: 9.097

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