Literature DB >> 25869315

Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates.

Pratibha Dwivedi1, Kunj B Mishra, Bhuwan B Mishra, Nisha Singh, Rakesh K Singh, Vinod K Tiwari.   

Abstract

The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani. Graphical Abstract Click Inspired Synthesis of Antileishmanial Triazolyl O-Benzylquercetin Glycoconjugates.

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Year:  2015        PMID： 25869315     DOI： 10.1007/s10719-015-9582-x

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  23 in total

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Authors:  Nisha Singh; Bhuwan B Mishra; Surabhi Bajpai; Rakesh K Singh; Vinod K Tiwari
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Review 2.  Carbohydrate based potential chemotherapeutic agents: recent developments and their scope in future drug discovery.

Authors:  Vinod K Tiwari; Ram C Mishra; Anindra Sharma; Rama P Tripathi
Journal:  Mini Rev Med Chem       Date:  2012-12       Impact factor: 3.862

Review 3.  Advances in the biotechnological glycosylation of valuable flavonoids.

Authors:  Jianbo Xiao; Tamar S Muzashvili; Milen I Georgiev
Journal:  Biotechnol Adv       Date:  2014-04-26       Impact factor: 14.227

4.  Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis.

Authors:  B Mittra; A Saha; A R Chowdhury; C Pal; S Mandal; S Mukhopadhyay; S Bandyopadhyay; H K Majumder
Journal:  Mol Med       Date:  2000-06       Impact factor: 6.354

5.  Click chemistry inspired highly facile synthesis of triazolyl ethisterone glycoconjugates.

Authors:  Dhananjay Kumar; Kunj B Mishra; Bhuwan B Mishra; Saheli Mondal; Vinod K Tiwari
Journal:  Steroids       Date:  2013-12-05       Impact factor: 2.668

6.  Evolvosides C–E, flavonol-4'-O-triglycosides from evolvulus alsinoides and their anti-stress activity [corrected].

Authors:  Prasoon Gupta; Upasana Sharma; Praveen Gupta; Kiran Babu Siripurapu; Rakesh Maurya
Journal:  Bioorg Med Chem       Date:  2013-01-10       Impact factor: 3.641

Review 7.  Recent applications of the Cu(I)-catalysed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in carbohydrate chemistry.

Authors:  Simone Dedola; Sergey A Nepogodiev; Robert A Field
Journal:  Org Biomol Chem       Date:  2007-03-05       Impact factor: 3.876

8.  Miltefosine in the treatment of leishmaniasis: Clinical evidence for informed clinical risk management.

Authors:  Shyam Sundar; Piero L Olliaro
Journal:  Ther Clin Risk Manag       Date:  2007-10       Impact factor: 2.423

9.  Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: synergistic effects with miltefosine.

Authors:  Maria C Sousa; Raquel Varandas; Rita C Santos; Manuel Santos-Rosa; Vera Alves; Jorge A R Salvador
Journal:  PLoS One       Date:  2014-03-18       Impact factor: 3.240

Review 10.  Biological roles of oligosaccharides: all of the theories are correct.

Authors:  A Varki
Journal:  Glycobiology       Date:  1993-04       Impact factor: 4.313
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  5 in total

1.  Click inspired synthesis of triazole-linked vanillin glycoconjugates.

Authors:  Pratibha Dwivedi; Kunj B Mishra; Bhuwan B Mishra; Vinod K Tiwari
Journal:  Glycoconj J       Date:  2016-10-03       Impact factor: 2.916

2.  Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors.

Authors:  Nidhi Mishra; Anand K Agrahari; Priyanka Bose; Sumit K Singh; Anoop S Singh; Vinod K Tiwari
Journal:  Sci Rep       Date:  2020-02-27       Impact factor: 4.379

3.  Iodine-mediated C-N and N-N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions.

Authors:  Geeta Sai Mani; Kavitha Donthiboina; Siddiq Pasha Shaik; Nagula Shankaraiah; Ahmed Kamal
Journal:  RSC Adv       Date:  2019-08-28       Impact factor: 4.036

4.  An expeditious click approach towards the synthesis of galactose coated novel glyco-dendrimers and dentromers utilizing a double stage convergent method.

Authors:  Anand K Agrahari; Anoop S Singh; Rishav Mukherjee; Vinod K Tiwari
Journal:  RSC Adv       Date:  2020-08-26       Impact factor: 4.036

5.  Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues.

Authors:  Adinarayana Nandikolla; Singireddi Srinivasarao; Banoth Karan Kumar; Sankaranarayanan Murugesan; Himanshu Aggarwal; Louise L Major; Terry K Smith; Kondapalli Venkata Gowri Chandra Sekhar
Journal:  RSC Adv       Date:  2020-10-19       Impact factor: 4.036
  5 in total

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