| Literature DB >> 24316164 |
Dhananjay Kumar1, Kunj B Mishra1, Bhuwan B Mishra1, Saheli Mondal1, Vinod K Tiwari2.
Abstract
Numerous deoxy-azido sugars 3 were prepared by the reaction of tosyl/bromo sugars with NaN3 in dry DMF under heating condition. The 1,3-dipolar cycloaddition of deoxy-azido sugars 3 with ethisterone 4 to afford regioselective triazole-linked ethisterone glycoconjugates 5 was investigated in the presence of CuI and DIPEA in dichloromethane or CuSO4·5H2O and sodium ascorbate in aqueous medium. All the developed compounds were characterized by spectroscopic analysis (IR, (1)H &(13)C NMR, and MS spectra). Structure of triazolyl ethisterone glycoconjugate 5a has been further confirmed by its Single Crystal X-ray analysis.Entities:
Keywords: Carbohydrate; Click chemistry; Ethisterone; Glycoconjugate
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Year: 2013 PMID： 24316164 DOI： 10.1016/j.steroids.2013.11.022
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668