| Literature DB >> 25868452 |
Ronnie H Fang1, Brian T Luk1, Che-Ming J Hu2, Liangfang Zhang3.
Abstract
Protein toxins secreted from pathogenic bacteria and venomous animals rely on multiple mechanisms to overcome the cell membrane barrier to inflict their virulence effect. A promising therapeutic concept toward developing a broadly applicable anti-toxin platform is to administer cell membrane mimics as decoys to sequester these virulence factors. As such, lipid membrane-based nanoparticulates are an ideal candidate given their structural similarity to cellular membranes. This article reviews the virulence mechanisms employed by toxins at the cell membrane interface and highlights the application of cell-membrane mimicking nanoparticles as toxin decoys for systemic detoxification. In addition, the implication of particle/toxin nanocomplexes in the development of toxoid vaccines is discussed.Entities:
Keywords: Anti-toxin nanoparticles; Cell membranes; Detoxification; Liposomes; Nanosponges; Virulence factors
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Year: 2015 PMID： 25868452 PMCID： PMC4547889 DOI： 10.1016/j.addr.2015.04.001
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470