Literature DB >> 20023663

Shiga toxins--from cell biology to biomedical applications.

Ludger Johannes1, Winfried Römer.   

Abstract

Shiga toxin-producing Escherichia coli is an emergent pathogen that can induce haemolytic uraemic syndrome. The toxin has received considerable attention not only from microbiologists but also in the field of cell biology, where it has become a powerful tool to study intracellular trafficking. In this Review, we summarize the Shiga toxin family members and their structures, receptors, trafficking pathways and cellular targets. We discuss how Shiga toxin affects cells not only by inhibiting protein biosynthesis but also through the induction of signalling cascades that lead to apoptosis. Finally, we discuss how Shiga toxins might be exploited in cancer therapy and immunotherapy.

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Year:  2009        PMID： 20023663     DOI： 10.1038/nrmicro2279

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  165 in total

1.  Shiga toxin induces tubular membrane invaginations for its uptake into cells.

Authors:  Winfried Römer; Ludwig Berland; Valérie Chambon; Katharina Gaus; Barbara Windschiegl; Danièle Tenza; Mohamed R E Aly; Vincent Fraisier; Jean-Claude Florent; David Perrais; Christophe Lamaze; Graça Raposo; Claudia Steinem; Pierre Sens; Patricia Bassereau; Ludger Johannes
Journal:  Nature       Date:  2007-11-29       Impact factor: 49.962

2.  Structure of the shiga-like toxin I B-pentamer complexed with an analogue of its receptor Gb3.

Authors:  H Ling; A Boodhoo; B Hazes; M D Cummings; G D Armstrong; J L Brunton; R J Read
Journal:  Biochemistry       Date:  1998-02-17       Impact factor: 3.162

3.  The B subunit of Shiga toxin fused to a tumor antigen elicits CTL and targets dendritic cells to allow MHC class I-restricted presentation of peptides derived from exogenous antigens.

Authors:  N Haicheur; E Bismuth; S Bosset; O Adotevi; G Warnier; V Lacabanne; A Regnault; C Desaymard; S Amigorena; P Ricciardi-Castagnoli; B Goud; W H Fridman; L Johannes; E Tartour
Journal:  J Immunol       Date:  2000-09-15       Impact factor: 5.422

4.  Inhibition of p38 mitogen-activated protein kinase ameliorates cytokine up-regulated shigatoxin-1 toxicity in human brain microvascular endothelial cells.

Authors:  Peter K Stricklett; Alisa K Hughes; Donald E Kohan
Journal:  J Infect Dis       Date:  2004-12-22       Impact factor: 5.226

5.  Tumor necrosis factor alpha increases human cerebral endothelial cell Gb3 and sensitivity to Shiga toxin.

Authors:  P B Eisenhauer; P Chaturvedi; R E Fine; A J Ritchie; J S Pober; T G Cleary; D S Newburg
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441

6.  Modelling of the interaction of verotoxin-1 (VT1) with its glycolipid receptor, globotriaosylceramide (Gb3).

Authors:  P G Nyholm; J L Brunton; C A Lingwood
Journal:  Int J Biol Macromol       Date:  1995-06       Impact factor: 6.953

7.  The B subunit of Shiga toxin coupled to full-size antigenic protein elicits humoral and cell-mediated immune responses associated with a Th1-dominant polarization.

Authors:  Nacilla Haicheur; Fabrice Benchetrit; Mohamed Amessou; Claude Leclerc; Thomas Falguières; Catherine Fayolle; Emmanuelle Bismuth; Wolf H Fridman; Ludger Johannes; Eric Tartour
Journal:  Int Immunol       Date:  2003-10       Impact factor: 4.823

8.  Cytotoxicity of Shigella dysenteriae 1 for cultured mammalian cells.

Authors:  T L Hale; S B Formal
Journal:  Am J Clin Nutr       Date:  1980-11       Impact factor: 7.045

9.  Differentiation-associated toxin receptor modulation, cytokine production, and sensitivity to Shiga-like toxins in human monocytes and monocytic cell lines.

Authors:  B Ramegowda; V L Tesh
Journal:  Infect Immun       Date:  1996-04       Impact factor: 3.441

10.  p38 mitogen-activated protein kinase mediates lipopolysaccharide and tumor necrosis factor alpha induction of shiga toxin 2 sensitivity in human umbilical vein endothelial cells.

Authors:  Matthew K Stone; Glynis L Kolling; Matthew H Lindner; Tom G Obrig
Journal:  Infect Immun       Date:  2007-12-17       Impact factor: 3.441
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  180 in total

Review 1.  Shiga toxin-associated hemolytic uremic syndrome: advances in pathogenesis and therapeutics.

Authors:  Tania N Petruzziello-Pellegrini; Philip A Marsden
Journal:  Curr Opin Nephrol Hypertens       Date:  2012-07       Impact factor: 2.894

2.  Verotoxin 2 enhances adherence of enterohemorrhagic Escherichia coli O157:H7 to intestinal epithelial cells and expression of {beta}1-integrin by IPEC-J2 cells.

Authors:  Bianfang Liu; Xianhua Yin; Yanni Feng; James R Chambers; Aiguang Guo; Joshua Gong; Jing Zhu; Carlton L Gyles
Journal:  Appl Environ Microbiol       Date:  2010-05-07       Impact factor: 4.792

3.  Analyzing of expression of novel polypeptide complexes consisting of Shiga toxin B subunit and Adherence Fimbriae of Escherichia coli based on in silico modeling.

Authors:  Zeinab Noroozian; Mana Oloomi; Saeid Bouzari
Journal:  J Mol Model       Date:  2012-04-24       Impact factor: 1.810

Review 4.  Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.

Authors:  Alfred H Merrill
Journal:  Chem Rev       Date:  2011-09-26       Impact factor: 60.622

5.  AGAP2 regulates retrograde transport between early endosomes and the TGN.

Authors:  Yoko Shiba; Winfried Römer; Gonzalo A Mardones; Patricia V Burgos; Christophe Lamaze; Ludger Johannes
Journal:  J Cell Sci       Date:  2010-06-15       Impact factor: 5.285

6.  Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells.

Authors:  Valeriy Lukyanenko; Irina Malyukova; Ann Hubbard; Michael Delannoy; Edgar Boedeker; Chengru Zhu; Liudmila Cebotaru; Olga Kovbasnjuk
Journal:  Am J Physiol Cell Physiol       Date:  2011-08-10       Impact factor: 4.249

7.  Top-down proteomic identification of Shiga toxin 2 subtypes from Shiga toxin-producing Escherichia coli by matrix-assisted laser desorption ionization-tandem time of flight mass spectrometry.

Authors:  Clifton K Fagerquist; William J Zaragoza; Omar Sultan; Nathan Woo; Beatriz Quiñones; Michael B Cooley; Robert E Mandrell
Journal:  Appl Environ Microbiol       Date:  2014-02-28       Impact factor: 4.792

Review 8.  Thermal control of virulence factors in bacteria: a hot topic.

Authors:  Oliver Lam; Jun Wheeler; Christoph M Tang
Journal:  Virulence       Date:  2014       Impact factor: 5.882

Review 9.  [Acute diarrheal disease caused by enteropathogenic Escherichia coli in Colombia].

Authors:  Oscar G Gómez-Duarte
Journal:  Rev Chilena Infectol       Date:  2014-10       Impact factor: 0.520

Review 10.  Recent advances in understanding enteric pathogenic Escherichia coli.

Authors:  Matthew A Croxen; Robyn J Law; Roland Scholz; Kristie M Keeney; Marta Wlodarska; B Brett Finlay
Journal:  Clin Microbiol Rev       Date:  2013-10       Impact factor: 26.132
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