Literature DB >> 25868448

Automated DNA profile analysis.

Eleanor A M Graham1.   

Abstract

DNA profile analysis is not a simple process. Stringent demands are placed on the accuracy and consistency of forensic evidence so that complex, robust, and reproducible guidelines are necessary to assist the analyst and ensure mistakes are eliminated before a final profile is reported. The guidelines used for forensic DNA profile interpretation are formulated by investigation and statistical evaluation of all aspects of the analytical procedure. All the resulting rules, formulas, and thresholds are perfectly suited to programming of "expert systems"-software programs that imitate the human expert in decision-based processes to formulate a conclusion. Expert systems in forensic DNA analysis will contribute greatly to this field by increasing analytical throughput. The net result of this will be an increase in the human resources available for the research and development of improved methodologies, to ensure that forensic DNA profiling continues to advance at its current impressive rate.

Entities:  

Year:  2005        PMID: 25868448     DOI: 10.1385/FSMP:1:4:285

Source DB:  PubMed          Journal:  Forensic Sci Med Pathol        ISSN: 1547-769X            Impact factor:   2.007


  11 in total

1.  Probabilistic expert systems for DNA mixture profiling.

Authors:  J Mortera; A P Dawid; S L Lauritzen
Journal:  Theor Popul Biol       Date:  2003-05       Impact factor: 1.570

2.  FINEX: a Probabilistic Expert System for forensic identification.

Authors:  Robert G Cowell
Journal:  Forensic Sci Int       Date:  2003-07-08       Impact factor: 2.395

3.  PENDULUM--a guideline-based approach to the interpretation of STR mixtures.

Authors:  Martin Bill; Peter Gill; James Curran; Tim Clayton; Richard Pinchin; Marcus Healy; John Buckleton
Journal:  Forensic Sci Int       Date:  2005-03-10       Impact factor: 2.395

4.  Interpreting simple STR mixtures using allele peak areas.

Authors:  P Gill; R Sparkes; R Pinchin; T Clayton; J Whitaker; J Buckleton
Journal:  Forensic Sci Int       Date:  1998-01-09       Impact factor: 2.395

Review 5.  Analysis and interpretation of mixed forensic stains using DNA STR profiling.

Authors:  T M Clayton; J P Whitaker; R Sparkes; P Gill
Journal:  Forensic Sci Int       Date:  1998-01-09       Impact factor: 2.395

6.  A new method of STR interpretation using inferential logic--development of a criminal intelligence database.

Authors:  P Gill; A Urquhart; E Millican; N Oldroyd; S Watson; R Sparkes; C P Kimpton
Journal:  Int J Legal Med       Date:  1996       Impact factor: 2.686

7.  Toward fully automated genotyping: genotyping microsatellite markers by deconvolution.

Authors:  M W Perlin; G Lancia; S K Ng
Journal:  Am J Hum Genet       Date:  1995-11       Impact factor: 11.025

8.  Development of guidelines to designate alleles using an STR multiplex system.

Authors:  P Gill; R Sparkes; C Kimpton
Journal:  Forensic Sci Int       Date:  1997-10-06       Impact factor: 2.395

9.  Toward fully automated genotyping: allele assignment, pedigree construction, phase determination, and recombination detection in Duchenne muscular dystrophy.

Authors:  M W Perlin; M B Burks; R C Hoop; E P Hoffman
Journal:  Am J Hum Genet       Date:  1994-10       Impact factor: 11.025

10.  A graphical simulation model of the entire DNA process associated with the analysis of short tandem repeat loci.

Authors:  Peter Gill; James Curran; Keith Elliot
Journal:  Nucleic Acids Res       Date:  2005-01-28       Impact factor: 16.971

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.