Giovanni Succo1, Erika Crosetti2, Andy Bertolin3, Marco Lucioni3, Giulia Arrigoni1, Valentina Panetta4, Andrea E Sprio5, Giovanni N Berta5, Giuseppe Rizzotto3. 1. Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy. 2. Otorhinolaryngology Service, Martini Hospital, Turin, Italy. 3. Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy. 4. L'altrastatistica srl, Consultancy and Training, Biostatistics Office, Rome, Italy. 5. Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Abstract
BACKGROUND: Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy is proposed as a function-sparing surgical technique. METHODS: We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3 to pT4a who underwent open partial horizontal laryngectomy. RESULTS: Five-year overall survival (OS), disease-free survival (DFS), locoregional control, local control, laryngectomy-free survival, and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3%, and 91.2%, respectively. DFS, locoregional control, and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7%, and 78.0%, respectively), whereas pN+ influenced only DFS (≤72.6%) and locoregional control (≤79.6%). CONCLUSIONS: Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension.
BACKGROUND: Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy is proposed as a function-sparing surgical technique. METHODS: We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3 to pT4a who underwent open partial horizontal laryngectomy. RESULTS: Five-year overall survival (OS), disease-free survival (DFS), locoregional control, local control, laryngectomy-free survival, and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3%, and 91.2%, respectively. DFS, locoregional control, and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7%, and 78.0%, respectively), whereas pN+ influenced only DFS (≤72.6%) and locoregional control (≤79.6%). CONCLUSIONS: Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension.
Authors: Andressa Silva de Freitas; Izabella C Santos; Cristina Furia; Rodrigo Dornelas; Ana Catarina Alves E Silva; Fernando Luiz Dias; Gil F Salles Journal: Eur Arch Otorhinolaryngol Date: 2022-01-04 Impact factor: 2.503
Authors: Andy Bertolin; Marco Lionello; Marco Ghizzo; Emanuela Barbero; Erika Crosetti; Giuseppe Rizzotto; Giovanni Succo Journal: Acta Otorhinolaryngol Ital Date: 2020-10 Impact factor: 2.124
Authors: E Crosetti; A Caracciolo; G Molteni; A E Sprio; G N Berta; L Presutti; G Succo Journal: Acta Otorhinolaryngol Ital Date: 2016-06 Impact factor: 2.124
Authors: Cesare Piazza; Marta Filauro; Alberto Paderno; Filippo Marchi; Pietro Perotti; Riccardo Morello; Stefano Taboni; Giampiero Parrinello; Fabiola Incandela; Andrea Iandelli; Francesco Missale; Giorgio Peretti Journal: Front Oncol Date: 2018-05-22 Impact factor: 6.244
Authors: E Crosetti; A Bertolin; G Molteni; I Bertotto; D Balmativola; M Carraro; A E Sprio; G N Berta; L Presutti; G Rizzotto; G Succo Journal: Acta Otorhinolaryngol Ital Date: 2019-08 Impact factor: 2.124