| Literature DB >> 25865348 |
Jingyuan Li1, Jifan Feng2, Yang Liu3, Thach-Vu Ho2, Weston Grimes2, Hoang Anh Ho2, Shery Park2, Songlin Wang4, Yang Chai5.
Abstract
During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs, such as teeth, hair follicles, mammary glands, and salivary glands. Interestingly, these ectodermal organs differ in their tissue homeostasis, which leads to differential abilities for continuous growth postnatally. Mouse molars lose the ability to grow continuously, whereas incisors retain this ability. In this study, we found that a BMP-Smad4-SHH-Gli1 signaling network may provide a niche supporting transient Sox2+ dental epithelial stem cells in mouse molars. This mechanism also plays a role in continuously growing mouse incisors. The differential fate of epithelial stem cells in mouse molars and incisors is controlled by this BMP/SHH signaling network, which partially accounts for the different postnatal growth potential of molars and incisors. Collectively, our study highlights the importance of crosstalk between two signaling pathways, BMP and SHH, in regulating the fate of epithelial stem cells during organogenesis.Entities:
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Year: 2015 PMID： 25865348 PMCID： PMC4406846 DOI： 10.1016/j.devcel.2015.02.021
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270