Literature DB >> 27905054

Crosstalk between SHH and stemness state signaling pathways in esophageal squamous cell carcinoma.

Maryam Najafi1, Mohammad Reza Abbaszadegan2, Abolfazl Rad3, Mahtab Dastpak4, Samaneh Boroumand-Noughabi5, Mohammad Mahdi Forghanifard6.   

Abstract

The expression of GLI1 as a downstream gene of sonic hedgehog (Hh) pathway, studied in a variety of cancers including esophageal squamous cell carcinoma (ESCC). However, the interaction of Hh with other developmental pathways needs to be elucidated. In this study, we aimed to investigate the correlation of GLI1 expression with transcription factors (TFs) of stem cell signaling pathways, and their association with clinico-pathological data of ESCC. Using real-time PCR, we assessed the expression of GLI1 mRNA in 49 ESCC patients, and analyzed the correlation between GLI1 and selected TFs. The results showed overexpression of GLI1 in ESCC tissues in significant correlation with lymph node metastasis. The GLI1 up-regulation was also correlated to the SOX2 and SIZN1 (Smad-interacting zinc finger protein) expression. These correlations may confirmed the role of GLI1 in crosstalk among different cell signaling pathways in ESCC. To our knowledge, this is the first study to demonstrate the correlation of GLI1 expression with stemness marker and BMP signaling in ESCC.

Entities:  

Keywords:  ESCC; GLI1 overexpression; SIZN1; SOX2; Stemness

Year:  2016        PMID： 27905054      PMCID： PMC5440343          DOI： 10.1007/s12079-016-0366-2

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  41 in total

1.  Negative Regulatory Role of TWIST1 on SNAIL Gene Expression.

Authors:  Mohammad Mahdi Forghanifard; Sima Ardalan Khales; Moein Farshchian; Abolfazl Rad; Masoud Homayouni-Tabrizi; Mohammad Reza Abbaszadegan
Journal:  Pathol Oncol Res       Date:  2016-07-20       Impact factor: 3.201

2.  Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis.

Authors:  Mohammad Mahdi Forghanifard; Omeed Moaven; Moein Farshchian; Mehdi Montazer; Reza Raeisossadati; Abbas Abdollahi; Meysam Moghbeli; Taher Nejadsattari; Kazem Parivar; Mohammad Reza Abbaszadegan
Journal:  Ann Surg Oncol       Date:  2011-10-18       Impact factor: 5.344

3.  Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients.

Authors:  Reza Raeisossadati; Moein Farshchian; Azita Ganji; Alieza Tavassoli; Arash Velayati; Ezzat Dadkhah; Somaye Chavoshi; Mostafa Mehrabi Bahar; Bahram Memar; Mohammad Taghi Rajabi Mashhadi; Hossein Naseh; Mohammad Mahdi Forghanifard; Meysam Moghbeli; Omeed Moaven; Mohammad Reza Abbaszadegan
Journal:  Int J Colorectal Dis       Date:  2011-05-15       Impact factor: 2.571

4.  TWIST1 upregulates the MAGEA4 oncogene.

Authors:  Mohammad Mahdi Forghanifard; Abolfazl Rad; Moein Farshchian; Maryam Khaleghizadeh; Mehran Gholamin; Meysam Moghbeli; Mohammad Reza Abbaszadegan
Journal:  Mol Carcinog       Date:  2016-10-04       Impact factor: 4.784

5.  The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.

Authors:  Karisa C Schreck; Pete Taylor; Luigi Marchionni; Vidya Gopalakrishnan; Eli E Bar; Nicholas Gaiano; Charles G Eberhart
Journal:  Clin Cancer Res       Date:  2010-12-15       Impact factor: 12.531

6.  A cancer-array approach elucidates the immune escape mechanism and defects in the DNA repair system in esophageal squamous cell carcinoma.

Authors:  Ezzat Dadkhah; Hossein Naseh; Moein Farshchian; Bahram Memar; Mojtaba Sankian; Reza Bagheri; Mohammad Mahdi Forghanifard; Mehdi Montazer; Mahboobeh Kazemi Noughabi; Mehrdad Hashemi; Mohammad Reza Abbaszadegan
Journal:  Arch Iran Med       Date:  2013-08       Impact factor: 1.354

7.  Role of Msi1 and PYGO2 in esophageal squamous cell carcinoma depth of invasion.

Authors:  Meysam Moghbeli; Ali Sadrizadeh; Mohammad Mahdi Forghanifard; Hooman Mosannen Mozaffari; Ebrahim Golmakani; Mohammad Reza Abbaszadegan
Journal:  J Cell Commun Signal       Date:  2015-12-07       Impact factor: 5.782

8.  SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties.

Authors:  Bruna Mascaro Cordeiro; Indhira Dias Oliveira; Maria Teresa de Seixas Alves; Nasjla Saba-Silva; Andrea M Capellano; Sergio Cavalheiro; Patrícia Dastoli; Silvia Regina Caminada Toledo
Journal:  Childs Nerv Syst       Date:  2014-04-03       Impact factor: 1.475

9.  Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy.

Authors:  R Yoshikawa; Y Nakano; L Tao; K Koishi; T Matsumoto; M Sasako; T Tsujimura; T Hashimoto-Tamaoki; Y Fujiwara
Journal:  Br J Cancer       Date:  2008-05-13       Impact factor: 7.640

Review 10.  Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks.

Authors:  Jingyu Zhang; Xiao-Jun Tian; Jianhua Xing
Journal:  J Clin Med       Date:  2016-03-28       Impact factor: 4.241
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  3 in total

1.  Mutations in the sonic hedgehog pathway cause macrocephaly-associated conditions due to crosstalk to the PI3K/AKT/mTOR pathway.

Authors:  Steven D Klein; Dzung C Nguyen; Viraj Bhakta; Derek Wong; Vivian Y Chang; Tom B Davidson; Julian A Martinez-Agosto
Journal:  Am J Med Genet A       Date:  2019-10-22       Impact factor: 2.578

Review 2.  Molecular Signaling in Tumorigenesis of Gastric Cancer

Authors:  Fatemeh Molaei; Mohammad Mahdi Forghanifard; Yasaman Fahim; Mohammad Reza Abbaszadegan
Journal:  Iran Biomed J       Date:  2018-04-30

3.  Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review).

Authors:  Rui-Jie Ma; Chao Ma; Kang Hu; Meng-Meng Zhao; Nan Zhang; Zhi-Gang Sun
Journal:  Int J Oncol       Date:  2022-07-20       Impact factor: 5.884
  3 in total

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