INTRODUCTION: Exercise has beneficial effects on cancer prevention as well as on prognosis of patients with cancer. To optimize the outcomes of exercise programs, more knowledge about the underlying mechanisms is needed. This study investigates the short-term effects of a half marathon on immune cell proportions, pro-inflammatory cytokine levels, and recovery behavior of patients with breast cancer in the aftercare compared to healthy controls. METHODS: Nine patients with breast cancer in the aftercare and 9 healthy age-matched controls participated in a half marathon. Blood samples were collected before, after, and 24 h after the run. Immune status was measured by flow cytometer analysis, while serum levels of the pro-inflammatory cytokines TNF-α, IL-6, and MIF were assessed using ELISA. Recovery behavior was determined using an ADL monitor. RESULTS: Both groups showed a similar recovery behavior and time courses in changes of granulocytes, monocytes, lymphocytes, and cytokine serum levels. Patients revealed increased proportions of cytotoxic and memory T cells, whereas helper and naïve T cells were decreased compared to healthy controls. Naïve and memory T-cell proportions were not affected by the intervention. CONCLUSIONS: Patients with breast cancer in the aftercare and healthy subjects show a similarly recovery behavior and immune response to the intervention. The detected differences in T-cell subsets need further investigation. Based on the results of the study, we hypothesize that immune cell subsets with known relevance in cancer were mobilized through the intervention. We confirm that the hypothesis of a midterm anti-inflammatory effect of exercise is also valid for patients with breast cancer in the aftercare.
INTRODUCTION: Exercise has beneficial effects on cancer prevention as well as on prognosis of patients with cancer. To optimize the outcomes of exercise programs, more knowledge about the underlying mechanisms is needed. This study investigates the short-term effects of a half marathon on immune cell proportions, pro-inflammatory cytokine levels, and recovery behavior of patients with breast cancer in the aftercare compared to healthy controls. METHODS: Nine patients with breast cancer in the aftercare and 9 healthy age-matched controls participated in a half marathon. Blood samples were collected before, after, and 24 h after the run. Immune status was measured by flow cytometer analysis, while serum levels of the pro-inflammatory cytokines TNF-α, IL-6, and MIF were assessed using ELISA. Recovery behavior was determined using an ADL monitor. RESULTS: Both groups showed a similar recovery behavior and time courses in changes of granulocytes, monocytes, lymphocytes, and cytokine serum levels. Patients revealed increased proportions of cytotoxic and memory T cells, whereas helper and naïve T cells were decreased compared to healthy controls. Naïve and memory T-cell proportions were not affected by the intervention. CONCLUSIONS:Patients with breast cancer in the aftercare and healthy subjects show a similarly recovery behavior and immune response to the intervention. The detected differences in T-cell subsets need further investigation. Based on the results of the study, we hypothesize that immune cell subsets with known relevance in cancer were mobilized through the intervention. We confirm that the hypothesis of a midterm anti-inflammatory effect of exercise is also valid for patients with breast cancer in the aftercare.
Authors: Thorsten Schmidt; Walter Jonat; Daniela Wesch; Hans-Heinrich Oberg; Sabine Adam-Klages; Lisa Keller; Christoph Röcken; Christoph Mundhenke Journal: J Cancer Res Clin Oncol Date: 2018-01-05 Impact factor: 4.553
Authors: Niklas Joisten; Annette Rademacher; Wilhelm Bloch; Alexander Schenk; Max Oberste; Ulrik Dalgas; Dawn Langdon; Daniel Caminada; Mette-Triin Purde; Roman Gonzenbach; Jan Kool; Philipp Zimmer; Jens Bansi Journal: BMC Neurol Date: 2019-03-08 Impact factor: 2.474
Authors: Sebastian Proschinger; Niklas Joisten; Annette Rademacher; Marit L Schlagheck; David Walzik; Alan J Metcalfe; Max Oberste; Clemens Warnke; Wilhelm Bloch; Alexander Schenk; Jens Bansi; Philipp Zimmer Journal: BMC Neurol Date: 2019-12-06 Impact factor: 2.474
Authors: Lewis Kirkwood; Lesley Ingram-Sills; Mark Dunlop Taylor; Eva Malone; Geraint Florida-James Journal: Int J Environ Res Public Health Date: 2021-04-26 Impact factor: 3.390
Authors: Nasim Khosravi; Erik D Hanson; Vahid Farajivafa; William S Evans; Jordan T Lee; Eli Danson; Chad W Wagoner; Elizabeth P Harrell; Stephanie A Sullivan; Kirsten A Nyrop; Hyman B Muss; David B Bartlett; Brian C Jensen; Shahpar Haghighat; Mahdieh Molanouri Shamsi; Claudio L Battaglini Journal: Brain Behav Immun Health Date: 2021-03-22