Sophie Briand1, Emmanuelle Chalifoux2, Eric Tourville3, Serge Bourgault3, Mathieu Caissie3, Yvon Tardif3, Marcelle Giasson3, Jocelyne Boivin3, Caty Blanchette4, Benoit Cinq-Mars3. 1. Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval. Electronic address: sophiebriand@hotmail.com. 2. Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval. 3. Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec. 4. Axe Santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Quebec, Que.
Abstract
OBJECTIVE: To compare macular hole (MH) closure and visual acuity improvement after vitrectomy using SF6 versus C3F8 gas tamponade. The secondary purposes were to report the cumulative incidence of cataract development at 1 year after MH surgery and the proportion of complications. DESIGN: Prospective, randomized study. PARTICIPANTS: Thirty-one patients were prospectively randomized to the SF6group and 28 patients to the C3F8 group. METHODS: Preoperative data included MH minimum diameter, Early Treatment Diabetic Retinopathy Study (ETDRS) best corrected visual acuity (BCVA), cataract staging, and intraocular pressure (IOP) measurement. Postoperative data included optical coherence tomography confirmation of the closure at 6 weeks and 1 year, and ETDRS BCVA and cataract development/extraction, both 1 year after the MH surgery. RESULTS:Primary MH closure was achieved in 93.3% in the SF6 group and 92.9% in the C3F8 group. MeanETDRS BCVA improved by 17.7 letters in the SF6 and 16.9 letters in the C3F8 group. The difference in cumulative incidence of cataract development and extraction between both groups was not statistically significant. Regardless of the dye used, similar results were achieved. Finally, the proportion of adverse events was similar in both groups. CONCLUSIONS: MH surgery with SF6 gas achieves results similar to C3F8 in terms of visual acuity improvement, MH closure, cataract development/extraction, and adverse events.
RCT Entities:
OBJECTIVE: To compare macular hole (MH) closure and visual acuity improvement after vitrectomy using SF6 versus C3F8 gas tamponade. The secondary purposes were to report the cumulative incidence of cataract development at 1 year after MH surgery and the proportion of complications. DESIGN: Prospective, randomized study. PARTICIPANTS: Thirty-one patients were prospectively randomized to the SF6 group and 28 patients to the C3F8 group. METHODS: Preoperative data included MH minimum diameter, Early Treatment Diabetic Retinopathy Study (ETDRS) best corrected visual acuity (BCVA), cataract staging, and intraocular pressure (IOP) measurement. Postoperative data included optical coherence tomography confirmation of the closure at 6 weeks and 1 year, and ETDRS BCVA and cataract development/extraction, both 1 year after the MH surgery. RESULTS: Primary MH closure was achieved in 93.3% in the SF6 group and 92.9% in the C3F8 group. Mean ETDRS BCVA improved by 17.7 letters in the SF6 and 16.9 letters in the C3F8 group. The difference in cumulative incidence of cataract development and extraction between both groups was not statistically significant. Regardless of the dye used, similar results were achieved. Finally, the proportion of adverse events was similar in both groups. CONCLUSIONS: MH surgery with SF6 gas achieves results similar to C3F8 in terms of visual acuity improvement, MH closure, cataract development/extraction, and adverse events.
Authors: Raul Velez-Montoya; J Abel Ramirez-Estudillo; Carl Sjoholm-Gomez de Liano; Francisco Bejar-Cornejo; Jorge Sanchez-Ramos; Jose Luis Guerrero-Naranjo; Virgilio Morales-Canton; Sergio E Hernandez-Da Mota Journal: Int J Retina Vitreous Date: 2018-02-19