| Literature DB >> 25862500 |
Yoshihiro Nakamura1, Shigeru Miyaki2, Hiroyuki Ishitobi3, Sho Matsuyama4, Tomoyuki Nakasa4, Naosuke Kamei2, Takayuki Akimoto5, Yukihito Higashi3, Mitsuo Ochi4.
Abstract
Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.Entities:
Keywords: Exosome; Mesenchymal stem cell; MicroRNA; Regeneration; Skeletal muscle
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Year: 2015 PMID： 25862500 DOI： 10.1016/j.febslet.2015.03.031
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124