Literature DB >> 2586231

Alpha-oxidation of alpha-hydroxyfatty acids in rat brain. Possible involvement of an alpha-peroxylactone.

M Salim-Hanna1, A Campa, G Cilento.   

Abstract

Combined--but not individual--microsomal and supernatant fractions obtained from rat brains not only consume oxygen but also provoke emission from added chlorophyll. These results are consistent with literature data (Levis and Mead, J. Biol. Chem. 239, 77 [1964]) for trapping of radioactive 14CO2 following addition of alpha-hydroxy-[1-14C]stearic acid. The most plausible explanation for emission is the interaction of chlorophyll with an alpha-peroxylactone. An intermediary alpha-peroxylactone in alpha-oxidation is consistent with other available data (Salim-Hanna, Campa and Cilento, Photochem. Photobiol. 45, 849 [1987]; Campa, Salim-Hanna and Cilento, Photochem. Photobiol. 49, 349 [1989]) and, on chemical grounds, provides a feasible route to the final products.

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Year:  1989        PMID： 2586231     DOI： 10.1007/bf02535217

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  4 in total

1.  AN ALPHA-HYDROXY ACID DECARBOXYLASE IN BRAIN MICROSOMES.

Authors:  G M LEVIS; J F MEAD
Journal:  J Biol Chem       Date:  1964-01       Impact factor: 5.157

2.  Fat metabolism in higher plants. XII. alpha-Oxidation of long chain fatty acids.

Authors:  R O MARTIN; P K STUMPF
Journal:  J Biol Chem       Date:  1959-10       Impact factor: 5.157

3.  Visible chemiluminescence from rat brain homogenates undergoing autoxidation. II. Kinetics of the luminescence decay.

Authors:  E A Lissi; T Cáceres; L A Videla
Journal:  Free Radic Biol Med       Date:  1988       Impact factor: 7.376

4.  Fat metabolism in higher plants. Recent studies on plant alpha-oxidation systems.

Authors:  W E Shine; P K Stumpf
Journal:  Arch Biochem Biophys       Date:  1974-05       Impact factor: 4.013
  4 in total
  3 in total

1.  Intermediates and products formed during fatty acid alpha-oxidation in cucumber (Cucumis sativus).

Authors:  G I Borge; G Vogt; A Nilsson
Journal:  Lipids       Date:  1999-07       Impact factor: 1.880

2.  2-Hydroxyhexadecanoic and 8,9,13-trihydroxydocosanoic acid accumulation by yeasts treated with fumonisin B1.

Authors:  T Kaneshiro; R F Vesonder; R E Peterson; M O Bagby
Journal:  Lipids       Date:  1993-05       Impact factor: 1.880

3.  Comparison of fatty acid alpha-oxidation by rat hepatocytes and by liver microsomes fortified with NADPH, Fe3+ and phosphate.

Authors:  S Huang; P P Van Veldhoven; S Asselberghs; H J Eyssen; E de Hoffmann; G P Mannaerts
Journal:  Lipids       Date:  1994-10       Impact factor: 1.880
  3 in total

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