Ramalingam Sripradha1, Sridhar Gopalakrishna Magadi2. 1. Scholar, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherr, India . 2. Senior Professor, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry, India .
Abstract
INTRODUCTION: Obesity leads to derangements in lipid and glucose homeostasis resulting in various metabolic complications. Plants containing vital phytochemicals are known to posses anti obesity properties and have proved to exert beneficial effects in obesity. OBJECTIVES: The present study was aimed to investigate the effects of Garcinia Cambogia on body weight, glucose tolerance and inflammation in high fat diet fed male Wistar rats. MATERIALS AND METHODS: Five month old male wistar rats (n=40) were divided into four groups. Two groups were fed with standard rodent diet and the remaining two with 30% high fat diet. One group in each of the two sets received the crude ethanolic extract of Garcinia Cambogia at a dose of 400mg/kg body weight/day for ten weeks. Body weight, intraperitoneal glucose tolerance test, leptin, tumour necrosis factor-α (TNF-α) and renal function (urea, creatinine, uric acid) were studied. RESULTS: High fat diet fed rats showed increased body weight gain, glucose intolerance, elevated levels of plasma leptin and TNF-α. Supplementation of Garcinia Cambogia extract (GE) along with high fat diet significantly decreased body weight gain, glucose intolerance, plasma leptin and TNF-α level. No significant changes were observed in the renal function parameters in any of the groups. CONCLUSION: Supplementation of the Garcinia Cambogia extract with high fat diet reduced body weight gain, inflammation and glucose intolerance.
INTRODUCTION:Obesity leads to derangements in lipid and glucose homeostasis resulting in various metabolic complications. Plants containing vital phytochemicals are known to posses anti obesity properties and have proved to exert beneficial effects in obesity. OBJECTIVES: The present study was aimed to investigate the effects of Garcinia Cambogia on body weight, glucose tolerance and inflammation in high fat diet fed male Wistar rats. MATERIALS AND METHODS: Five month old male wistar rats (n=40) were divided into four groups. Two groups were fed with standard rodent diet and the remaining two with 30% high fat diet. One group in each of the two sets received the crude ethanolic extract of Garcinia Cambogia at a dose of 400mg/kg body weight/day for ten weeks. Body weight, intraperitoneal glucose tolerance test, leptin, tumour necrosis factor-α (TNF-α) and renal function (urea, creatinine, uric acid) were studied. RESULTS: High fat diet fed rats showed increased body weight gain, glucose intolerance, elevated levels of plasma leptin and TNF-α. Supplementation of Garcinia Cambogia extract (GE) along with high fat diet significantly decreased body weight gain, glucose intolerance, plasma leptin and TNF-α level. No significant changes were observed in the renal function parameters in any of the groups. CONCLUSION: Supplementation of the Garcinia Cambogia extract with high fat diet reduced body weight gain, inflammation and glucose intolerance.
Authors: Bruna Larissa Spontoni do Espirito Santo; Lidiani Figueiredo Santana; Wilson Hino Kato Junior; Felipe de Oliveira de Araújo; Danielle Bogo; Karine de Cássia Freitas; Rita de Cássia Avellaneda Guimarães; Priscila Aiko Hiane; Arnildo Pott; Wander Fernando de Oliveira Filiú; Marcel Arakaki Asato; Patrícia de Oliveira Figueiredo; Paulo Roberto Haidamus de Oliveira Bastos Journal: Molecules Date: 2020-10-01 Impact factor: 4.411
Authors: Nguyen Hoai Nguyen; Minh Tan Nguyen; Hiep Dinh Nguyen; Phuoc Dien Pham; Ut Dong Thach; Binh T D Trinh; Ly T T Nguyen; Son V Dang; Anh Thu Do; Bich Hang Do Journal: Evid Based Complement Alternat Med Date: 2021-06-18 Impact factor: 2.629