Literature DB >> 25857949

Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: Mechanisms and epidemiology.

Anaïs Potron1, Laurent Poirel2, Patrice Nordmann3.   

Abstract

Multidrug resistance is quite common among non-fermenting Gram-negative rods, in particular among clinically relevant species including Pseudomonas aeruginosa and Acinetobacter baumannii. These bacterial species, which are mainly nosocomial pathogens, possess a diversity of resistance mechanisms that may lead to multidrug or even pandrug resistance. Extended-spectrum β-lactamases (ESBLs) conferring resistance to broad-spectrum cephalosporins, carbapenemases conferring resistance to carbapenems, and 16S rRNA methylases conferring resistance to all clinically relevant aminoglycosides are the most important causes of concern. Concomitant resistance to fluoroquinolones, polymyxins (colistin) and tigecycline may lead to pandrug resistance. The most important mechanisms of resistance in P. aeruginosa and A. baumannii and their most recent dissemination worldwide are detailed here.
Copyright © 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Entities:  

Keywords:  Acinetobacter baumannii; Aminoglycosides; Carbapenems; Multidrug resistance; Pseudomonas aeruginosa; β-Lactams

Mesh：

Substances：

Year:  2015        PMID： 25857949     DOI： 10.1016/j.ijantimicag.2015.03.001

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  195 in total

1.  Co-production of AmpC and extended spectrum beta-lactamases in cephalosporin-resistant Acinetobacter baumannii in Egypt.

Authors:  Heba Shehta Said; Abdalbagi Basheer Benmahmod; Ramadan Hassan Ibrahim
Journal:  World J Microbiol Biotechnol       Date:  2018-12-03       Impact factor: 3.312

2.  Predictors of Mortality in Bloodstream Infections Caused by Pseudomonas aeruginosa and Impact of Antimicrobial Resistance and Bacterial Virulence.

Authors:  Raúl Recio; Mikel Mancheño; Esther Viedma; Jennifer Villa; María Ángeles Orellana; Jaime Lora-Tamayo; Fernando Chaves
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

3.  First Occurrence of OXA-72-Producing Acinetobacter baumannii in Serbia.

Authors:  Laurent Dortet; Rémy A Bonnin; Sandrine Bernabeu; Lélia Escaut; Daniel Vittecoq; Delphine Girlich; Dilek Imanci; Nicolas Fortineau; Thierry Naas
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

4.  Identification of 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol, a Novel Antibacterial Compound Active against Persisters of Pseudomonas aeruginosa.

Authors:  Veerle Liebens; Valerie Defraine; Wouter Knapen; Toon Swings; Serge Beullens; Romu Corbau; Arnaud Marchand; Patrick Chaltin; Maarten Fauvart; Jan Michiels
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

Review 5.  Therapies for multidrug resistant and extensively drug-resistant non-fermenting gram-negative bacteria causing nosocomial infections: a perilous journey toward 'molecularly targeted' therapy.

Authors:  Nadim G El Chakhtoura; Elie Saade; Alina Iovleva; Mohamad Yasmin; Brigid Wilson; Federico Perez; Robert A Bonomo
Journal:  Expert Rev Anti Infect Ther       Date:  2018-01-16       Impact factor: 5.091

6.  Characterization of the pJB12 Plasmid from Pseudomonas aeruginosa Reveals Tn6352, a Novel Putative Transposon Associated with Mobilization of the blaVIM-2-Harboring In58 Integron.

Authors:  João Botelho; Filipa Grosso; Luísa Peixe
Journal:  Antimicrob Agents Chemother       Date:  2017-04-24       Impact factor: 5.191

7.  In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii-calcoaceticus Complex Isolates Collected Globally in 2016 and 2017.

Authors:  Sarah M McLeod; Samir H Moussa; Meredith A Hackel; Alita A Miller
Journal:  Antimicrob Agents Chemother       Date:  2020-03-24       Impact factor: 5.191

8.  Imipenem-resistant Gram-negative bacterial isolates carried by persons upon medical examination in Korea.

Authors:  So Yeon Kim; Sang Yop Shin; Ji-Young Rhee; Kwan Soo Ko
Journal:  J Microbiol       Date:  2017-07-18       Impact factor: 3.422

9.  Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection.

Authors:  Kelly L Michie; Justine L Dees; Derek Fleming; Dina A Moustafa; Joanna B Goldberg; Kendra P Rumbaugh; Marvin Whiteley
Journal:  Infect Immun       Date:  2020-05-20       Impact factor: 3.441

Review 10.  β-lactam/β-lactamase inhibitor combinations: an update.

Authors:  Kamaleddin H M E Tehrani; Nathaniel I Martin
Journal:  Medchemcomm       Date:  2018-08-17       Impact factor: 3.597
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