| Literature DB >> 28193652 |
João Botelho1, Filipa Grosso1, Luísa Peixe2.
Abstract
The blaVIM-2-carrying In58 integron has been linked to a chromosomal location in different bacterial species, including Pseudomonas aeruginosa This work reports the first fully sequenced In58-harboring plasmid, which is significantly different from the two previously identified blaVIM-2-carrying plasmids in P. aeruginosablaVIM-2 might have been acquired by transposition of Tn6352, a novel transposon composed of the In58 and ISPa17 elements. The recognition of similar inverted repeat (IR) sites by ISPa17 reveals a common mobilization process associated with acquisition of the blaVIM-2 and blaVIM-1 genes.Entities:
Keywords: Pseudomonas aeruginosa; carbapenemase; plasmid-mediated resistance; transposon
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Year: 2017 PMID: 28193652 PMCID: PMC5404595 DOI: 10.1128/AAC.02532-16
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191