CONTEXT: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. OBJECTIVE: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. METHODS: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. RESULTS AND CONCLUSION: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.
CONTEXT: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. OBJECTIVE: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. METHODS: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. RESULTS AND CONCLUSION: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of humantumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.
Entities:
Keywords:
Calcitriol; Vitamin D analogues; cancer prevention
Authors: Hannah B Mandle; Ferdous A Jahan; Roberd M Bostick; John A Baron; Elizabeth L Barry; Rami Yacoub; Julia Merrill; Robin E Rutherford; March E Seabrook; Veronika Fedirko Journal: Mol Carcinog Date: 2019-04-02 Impact factor: 4.784
Authors: Stephanie J Weinstein; Alison M Mondul; Tracy M Layne; Kai Yu; Jiaqi Huang; Rachael Z Stolzenberg-Solomon; Regina G Ziegler; Mark P Purdue; Wen-Yi Huang; Christian C Abnet; Neal D Freedman; Demetrius Albanes Journal: JNCI Cancer Spectr Date: 2022-03-02
Authors: Silvia Migliaccio; Andrea Di Nisio; Silvia Magno; Fiammetta Romano; Luigi Barrea; Anna Maria Colao; Giovanna Muscogiuri; Silvia Savastano Journal: Int J Obes (Lond) Date: 2022-01-14 Impact factor: 5.551
Authors: Negar Khazan; Kyu Kwang Kim; Jeanne N Hansen; Niloy A Singh; Taylor Moore; Cameron W A Snyder; Ravina Pandita; Myla Strawderman; Michiko Fujihara; Yuta Takamura; Ye Jian; Nicholas Battaglia; Naohiro Yano; Yuki Teramoto; Leggy A Arnold; Russell Hopson; Keshav Kishor; Sneha Nayak; Debasmita Ojha; Ashoke Sharon; John M Ashton; Jian Wang; Michael T Milano; Hiroshi Miyamoto; David C Linehan; Scott A Gerber; Nada Kawar; Ajay P Singh; Erdem D Tabdanov; Nikolay V Dokholyan; Hiroki Kakuta; Peter W Jurutka; Nina F Schor; Rachael B Rowswell-Turner; Rakesh K Singh; Richard G Moore Journal: J Med Chem Date: 2022-04-11 Impact factor: 8.039
Authors: Yeon Soo Jung; Hee Jung Kim; Seok Kyo Seo; Young Sik Choi; Eun Ji Nam; Sunghoon Kim; Sang Wun Kim; Hyuck Dong Han; Jae Wook Kim; Young Tae Kim Journal: Yonsei Med J Date: 2016-01 Impact factor: 2.759