M Constantine Samaan1,2, Noori Akhtar-Danesh3,4. 1. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. 2. Division of Pediatric Endocrinology, McMaster Children's Hospital, Hamilton, Ontario, Canada. 3. School of Nursing, McMaster University, Hamilton, Ontario, Canada. 4. Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Abstract
OBJECTIVE: Despite improvements in pediatric brain tumor outcomes, the survivors of childhood brain tumor are burdened by multiple comorbidities. This work reports on the relative survival ratios and excess mortality rate in children with astrocytic tumors over the past four decades. METHODS: Survival analysis was conducted using flexible parametric model to estimate relative survival and excess mortality rate for non-white and white children (0-19 years old) using the Surveillance, Epidemiology & End Results (SEER) database. We incorporated age group and year of diagnosis into the model to estimate these indices for the period of 1973-2010. RESULTS: Progressive decline in relative survival ratios was noted over time. Non-white children had lower survival rates than white children, and these survival patterns persisted over the four-decade span of the study. Fifty percent of non-white survivors were deceased 30 years post diagnosis, compared to 35 years in white survivors. CONCLUSIONS: Survivors of childhood brain tumors have progressively lower survival rates as they get older, and this is higher in non-white when compared to white children. Future research efforts need to focus on understanding the factors mediating the effect of the tumor or its treatment on survival in these patients, and the ethnic variations that derive these survival trends.
OBJECTIVE: Despite improvements in pediatric brain tumor outcomes, the survivors of childhood brain tumor are burdened by multiple comorbidities. This work reports on the relative survival ratios and excess mortality rate in children with astrocytic tumors over the past four decades. METHODS: Survival analysis was conducted using flexible parametric model to estimate relative survival and excess mortality rate for non-white and white children (0-19 years old) using the Surveillance, Epidemiology & End Results (SEER) database. We incorporated age group and year of diagnosis into the model to estimate these indices for the period of 1973-2010. RESULTS: Progressive decline in relative survival ratios was noted over time. Non-white children had lower survival rates than white children, and these survival patterns persisted over the four-decade span of the study. Fifty percent of non-white survivors were deceased 30 years post diagnosis, compared to 35 years in white survivors. CONCLUSIONS: Survivors of childhood brain tumors have progressively lower survival rates as they get older, and this is higher in non-white when compared to white children. Future research efforts need to focus on understanding the factors mediating the effect of the tumor or its treatment on survival in these patients, and the ethnic variations that derive these survival trends.
Authors: David A Siegel; Jun Li; Helen Ding; Simple D Singh; Jessica B King; Lori A Pollack Journal: Pediatr Blood Cancer Date: 2018-10-23 Impact factor: 3.167
Authors: Kuan-Wen Wang; Marlie Valencia; Laura Banfield; Ruth Chau; Adam Fleming; Sheila K Singh; Sarah Burrow; Russell J de Souza; Lehana Thabane; M Constantine Samaan Journal: Syst Rev Date: 2016-06-14
Authors: E Danielle Sims; Kuan-Wen Wang; Adam Fleming; Donna L Johnston; Shayna M Zelcer; Shahrad Rod Rassekh; Sarah Burrow; Lehana Thabane; M Constantine Samaan Journal: Sci Rep Date: 2018-11-05 Impact factor: 4.379
Authors: Kuan-Wen Wang; Russell J de Souza; Adam Fleming; Donna L Johnston; Shayna M Zelcer; Shahrad Rod Rassekh; Sarah Burrow; Lehana Thabane; M Constantine Samaan Journal: Sci Rep Date: 2018-01-26 Impact factor: 4.379