Literature DB >> 25853778

Urinary tract infections: epidemiology, mechanisms of infection and treatment options.

Ana L Flores-Mireles1, Jennifer N Walker1, Michael Caparon2, Scott J Hultgren2.   

Abstract

Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.

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Year:  2015        PMID： 25853778      PMCID： PMC4457377          DOI： 10.1038/nrmicro3432

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  149 in total

1.  Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis.

Authors:  Xin Li; Jarrod L Erbe; C Virginia Lockatell; David E Johnson; Michael G Jobling; Randall K Holmes; Harry L T Mobley
Journal:  Infect Immun       Date:  2004-12       Impact factor: 3.441

Review 2.  Morphological plasticity as a bacterial survival strategy.

Authors:  Sheryl S Justice; David A Hunstad; Lynette Cegelski; Scott J Hultgren
Journal:  Nat Rev Microbiol       Date:  2008-02       Impact factor: 60.633

3.  Redundancy and specificity of Escherichia coli iron acquisition systems during urinary tract infection.

Authors:  Erin C Garcia; Ariel R Brumbaugh; Harry L T Mobley
Journal:  Infect Immun       Date:  2011-01-10       Impact factor: 3.441

Review 4.  Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.

Authors:  Maria Kostakioti; Maria Hadjifrangiskou; Scott J Hultgren
Journal:  Cold Spring Harb Perspect Med       Date:  2013-04-01       Impact factor: 6.915

5.  Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an alpha-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritis.

Authors:  P O'Hanley; G Lalonde; G Ji
Journal:  Infect Immun       Date:  1991-03       Impact factor: 3.441

6.  Urease. The primary cause of infection-induced urinary stones.

Authors:  D P Griffith; D M Musher; C Itin
Journal:  Invest Urol       Date:  1976-03

7.  In vivo and in vitro toxicity of phospholipase C from Pseudomonas aeruginosa.

Authors:  D J Meyers; K C Palmer; L A Bale; K Kernacki; M Preston; T Brown; R S Berk
Journal:  Toxicon       Date:  1992-02       Impact factor: 3.033

8.  Flagella allow uropathogenic Escherichia coli ascension into murine kidneys.

Authors:  William R Schwan
Journal:  Int J Med Microbiol       Date:  2007-09-20       Impact factor: 3.473

9.  Functional analysis of antigen 43 in uropathogenic Escherichia coli reveals a role in long-term persistence in the urinary tract.

Authors:  Glen C Ulett; Jaione Valle; Christophe Beloin; Orla Sherlock; Jean-Marc Ghigo; Mark A Schembri
Journal:  Infect Immun       Date:  2007-04-09       Impact factor: 3.441

10.  Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.

Authors:  Sarah E Greene; Jerome S Pinkner; Erik Chorell; Karen W Dodson; Carrie L Shaffer; Matt S Conover; Jonathan Livny; Maria Hadjifrangiskou; Fredrik Almqvist; Scott J Hultgren
Journal:  mBio       Date:  2014-10-28       Impact factor: 7.867
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  702 in total

1.  The Role of Gram-Negative Bacteria in Urinary Tract Infections: Current Concepts and Therapeutic Options.

Authors:  Payam Behzadi; Edit Urbán; Mária Matuz; Ria Benkő; Márió Gajdács
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 2.  The emerging threat of multidrug-resistant Gram-negative bacteria in urology.

Authors:  Hosam M Zowawi; Patrick N A Harris; Matthew J Roberts; Paul A Tambyah; Mark A Schembri; M Diletta Pezzani; Deborah A Williamson; David L Paterson
Journal:  Nat Rev Urol       Date:  2015-09-01       Impact factor: 14.432

Review 3.  Switching Rho GTPase activation into effective antibacterial defenses requires the caspase-1/IL-1beta signaling axis.

Authors:  Laurent Boyer; Emmanuel Lemichez
Journal:  Small GTPases       Date:  2015-10-22

4.  Direct Identification of Urinary Tract Pathogens from Urine Samples, Combining Urine Screening Methods and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.

Authors:  Melania Íñigo; Andreu Coello; Gema Fernández-Rivas; Belén Rivaya; Jessica Hidalgo; María Dolores Quesada; Vicente Ausina
Journal:  J Clin Microbiol       Date:  2016-01-27       Impact factor: 5.948

5.  Development of a panel of recombinase polymerase amplification assays for detection of common bacterial urinary tract infection pathogens.

Authors:  B Raja; H J Goux; A Marapadaga; S Rajagopalan; K Kourentzi; R C Willson
Journal:  J Appl Microbiol       Date:  2017-08       Impact factor: 3.772

6.  Aerococcus urinae Isolated from Women with Lower Urinary Tract Symptoms: In Vitro Aggregation and Genome Analysis.

Authors:  Evann E Hilt; Catherine Putonti; Krystal Thomas-White; Amanda L Lewis; Karen L Visick; Nicole M Gilbert; Alan J Wolfe
Journal:  J Bacteriol       Date:  2020-06-09       Impact factor: 3.490

Review 7.  A review on anti-adhesion therapies of bacterial diseases.

Authors:  Arezoo Asadi; Shabnam Razavi; Malihe Talebi; Mehrdad Gholami
Journal:  Infection       Date:  2018-10-01       Impact factor: 3.553

Review 8.  Urinary Tract Infection: Pathogenesis and Outlook.

Authors:  Lisa K McLellan; David A Hunstad
Journal:  Trends Mol Med       Date:  2016-09-28       Impact factor: 11.951

9.  Bladder catheterization increases susceptibility to infection that can be prevented by prophylactic antibiotic treatment.

Authors:  Matthieu Rousseau; H M Sharon Goh; Sarah Holec; Matthew L Albert; Rohan Bh Williams; Molly A Ingersoll; Kimberly A Kline
Journal:  JCI Insight       Date:  2016-09-22

10.  The Catabolite Repressor Protein-Cyclic AMP Complex Regulates csgD and Biofilm Formation in Uropathogenic Escherichia coli.

Authors:  David A Hufnagel; Margery L Evans; Sarah E Greene; Jerome S Pinkner; Scott J Hultgren; Matthew R Chapman
Journal:  J Bacteriol       Date:  2016-11-18       Impact factor: 3.490
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