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Literature DB >> 1557786

In vivo and in vitro toxicity of phospholipase C from Pseudomonas aeruginosa.

D J Meyers¹, K C Palmer, L A Bale, K Kernacki, M Preston, T Brown, R S Berk.

Abstract

Pseudomonas aeruginosa produces phospholipase C (PLC), a heat-labile hemolysin. Histopathological analysis of PLC-treated mice revealed that the primary target organs involved in PLC-induced toxicity were the liver and kidney. Mice treated i.v. with PLC demonstrated significant tubular epithelial necrosis of the kidney with hematuria, while when given i.p. they exhibited hepatonecrosis with cellular infiltration. Splenomegaly was also a consistent finding. Results from in vitro studies indicate that PLC is toxic for mouse peritoneal cells and human leukocytes.

Entities: Disease Species

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Year: 1992 PMID： 1557786 DOI： 10.1016/0041-0101(92)90469-l

Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033

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Cited

17 in total

1. Pseudomonas aeruginosa hemolytic phospholipase C suppresses neutrophil respiratory burst activity.

Authors: L S Terada; K A Johansen; S Nowbar; A I Vasil; M L Vasil
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Review 4. Bacterial phospholipases C.

Authors: R W Titball
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Authors: Mohammad-Saeid Jami; Carlos García-Estrada; Carlos Barreiro; Abel-Alberto Cuadrado; Zahra Salehi-Najafabadi; Juan-Francisco Martín
Journal: Mol Cell Proteomics Date: 2010-09-07 Impact factor: 5.911

In vivo and in vitro toxicity of phospholipase C from Pseudomonas aeruginosa.

1. Pseudomonas aeruginosa hemolytic phospholipase C suppresses neutrophil respiratory burst activity.

2. Cooperation between LepA and PlcH contributes to the in vivo virulence and growth of Pseudomonas aeruginosa in mice.

Review 3. Urinary tract infections: epidemiology, mechanisms of infection and treatment options.

Review 4. Bacterial phospholipases C.

5. The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology.

6. Evidence of multiple extracellular phospholipase activities of Aspergillus fumigatus.

7. Partial characterization of Streptococcus suis type 2 hemolysin.

8. GbdR regulates Pseudomonas aeruginosa plcH and pchP transcription in response to choline catabolites.

9. Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence.

10. Alterations in Pseudomonas aeruginosa exoproducts by sub-MICs of some antibiotics.