Literature DB >> 25853310

Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas.

Kaisorn L Chaichana1, Leon Pinheiro, Henry Brem.   

Abstract

Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized by their propensity to invade surrounding brain parenchyma, making curative resection difficult. These tumors typically recur within two centimeters of the resection cavity even after gross total removal. As a result, there has been an emphasis on developing therapeutics aimed at achieving local disease control. In this review, we will summarize the current developments in the delivery of local therapeutics, namely direct injection, convection-enhanced delivery and implantation of drug-loaded polymers, as well as the application of these therapeutics in future methods including microchip drug delivery and local gene therapy.

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Year:  2015        PMID： 25853310      PMCID： PMC4696051          DOI： 10.4155/tde.14.114

Source DB:  PubMed          Journal:  Ther Deliv        ISSN： 2041-5990


  121 in total

1.  Relationship of glioblastoma multiforme to the lateral ventricles predicts survival following tumor resection.

Authors:  Kaisorn L Chaichana; Matthew J McGirt; James Frazier; Frank Attenello; Hugo Guerrero-Cazares; Alfredo Quinones-Hinojosa
Journal:  J Neurooncol       Date:  2008-05-06       Impact factor: 4.130

2.  Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. Clinical article.

Authors:  Kaisorn L Chaichana; Aditya N Halthore; Scott L Parker; Alessandro Olivi; Jon D Weingart; Henry Brem; Alfredo Quinones-Hinojosa
Journal:  J Neurosurg       Date:  2010-06-04       Impact factor: 5.115

3.  Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model.

Authors:  Alexander W Scott; Betty M Tyler; Byron C Masi; Urvashi M Upadhyay; Yoda R Patta; Rachel Grossman; Luca Basaldella; Robert S Langer; Henry Brem; Michael J Cima
Journal:  Biomaterials       Date:  2011-01-08       Impact factor: 12.479

4.  Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. Clinical article.

Authors:  Kaisorn L Chaichana; Khan K Chaichana; Alessandro Olivi; Jon D Weingart; Richard Bennett; Henry Brem; Alfredo Quiñones-Hinojosa
Journal:  J Neurosurg       Date:  2010-10-01       Impact factor: 5.115

5.  Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients.

Authors:  Kaisorn L Chaichana; Tomas Garzon-Muvdi; Scott Parker; Jon D Weingart; Alessandro Olivi; Richard Bennett; Henry Brem; Alfredo Quiñones-Hinojosa
Journal:  Ann Surg Oncol       Date:  2010-08-10       Impact factor: 5.344

6.  Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.

Authors:  Jennifer A Quinn; Sara Xiaoyin Jiang; James Carter; David A Reardon; Annick Desjardins; James J Vredenburgh; Jeremy N Rich; Sridharan Gururangan; Allan H Friedman; Darell D Bigner; John H Sampson; Roger E McLendon; James E Herndon; Stevie Threatt; Henry S Friedman
Journal:  Clin Cancer Res       Date:  2009-02-01       Impact factor: 12.531

7.  Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme.

Authors:  Matthew J McGirt; Khoi D Than; Jon D Weingart; Kaisorn L Chaichana; Frank J Attenello; Alessandro Olivi; John Laterra; Lawrence R Kleinberg; Stuart A Grossman; Henry Brem; Alfredo Quiñones-Hinojosa
Journal:  J Neurosurg       Date:  2009-03       Impact factor: 5.115

8.  Independent association of extent of resection with survival in patients with malignant brain astrocytoma.

Authors:  Matthew J McGirt; Kaisorn L Chaichana; Muraya Gathinji; Frank J Attenello; Khoi Than; Alessandro Olivi; Jon D Weingart; Henry Brem; Alf Redo Quiñones-Hinojosa
Journal:  J Neurosurg       Date:  2009-01       Impact factor: 5.115

9.  Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery.

Authors:  Vanja Varenika; Peter Dickinson; John Bringas; Richard LeCouteur; Robert Higgins; John Park; Massimo Fiandaca; Mitchel Berger; John Sampson; Krystof Bankiewicz
Journal:  J Neurosurg       Date:  2008-11       Impact factor: 5.115

10.  An integrated genomic analysis of human glioblastoma multiforme.

Authors:  D Williams Parsons; Siân Jones; Xiaosong Zhang; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; I-Mei Siu; Gary L Gallia; Alessandro Olivi; Roger McLendon; B Ahmed Rasheed; Stephen Keir; Tatiana Nikolskaya; Yuri Nikolsky; Dana A Busam; Hanna Tekleab; Luis A Diaz; James Hartigan; Doug R Smith; Robert L Strausberg; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Hai Yan; Gregory J Riggins; Darell D Bigner; Rachel Karchin; Nick Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728
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  19 in total

Review 1.  Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain.

Authors:  Mayur M Patel; Bhoomika M Patel
Journal:  CNS Drugs       Date:  2017-02       Impact factor: 5.749

2.  Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide-loaded PLGA microparticles for the treatment of glioblastoma.

Authors:  Daniel A Rodriguez de Anda; Nareg Ohannesian; Karen S Martirosyan; Sue Anne Chew
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2019-02-15       Impact factor: 3.368

3.  Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.

Authors:  Clark Zhang; Elizabeth A Nance; Panagiotis Mastorakos; Jane Chisholm; Sneha Berry; Charles Eberhart; Betty Tyler; Henry Brem; Jung Soo Suk; Justin Hanes
Journal:  J Control Release       Date:  2017-03-07       Impact factor: 9.776

Review 4.  Nanoparticles for Targeting Intratumoral Hypoxia: Exploiting a Potential Weakness of Glioblastoma.

Authors:  Mihaela Aldea; Ioan Alexandru Florian; Gabriel Kacso; Lucian Craciun; Sanda Boca; Olga Soritau; Ioan Stefan Florian
Journal:  Pharm Res       Date:  2016-05-26       Impact factor: 4.200

Review 5.  Covalent nano delivery systems for selective imaging and treatment of brain tumors.

Authors:  Julia Y Ljubimova; Tao Sun; Leila Mashouf; Alexander V Ljubimov; Liron L Israel; Vladimir A Ljubimov; Vida Falahatian; Eggehard Holler
Journal:  Adv Drug Deliv Rev       Date:  2017-06-10       Impact factor: 15.470

Review 6.  Nanotherapeutic systems for local treatment of brain tumors.

Authors:  Rami Walid Chakroun; Pengcheng Zhang; Ran Lin; Paula Schiapparelli; Alfredo Quinones-Hinojosa; Honggang Cui
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2017-05-24

Review 7.  T cell immunotherapy enhanced by designer biomaterials.

Authors:  Zachary S Dunn; John Mac; Pin Wang
Journal:  Biomaterials       Date:  2019-06-14       Impact factor: 12.479

Review 8.  Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas.

Authors:  Brittany C Parker Kerrigan; Yuzaburo Shimizu; Michael Andreeff; Frederick F Lang
Journal:  Cytotherapy       Date:  2017-02-21       Impact factor: 5.414

Review 9.  Prospects of immune checkpoint modulators in the treatment of glioblastoma.

Authors:  Matthias Preusser; Michael Lim; David A Hafler; David A Reardon; John H Sampson
Journal:  Nat Rev Neurol       Date:  2015-08-11       Impact factor: 42.937

10.  Hyaluronic acid based low viscosity hydrogel as a novel carrier for Convection Enhanced Delivery of CAR T cells.

Authors:  Ahmet F Atik; Carter M Suryadevara; Ryan M Schweller; Jennifer L West; Patrick Healy; James E Herndon Ii; Kendra L Congdon; Luis Sanchez-Perez; Roger E McLendon; Gerald E Archer; Peter Fecci; John H Sampson
Journal:  J Clin Neurosci       Date:  2018-07-21       Impact factor: 1.961
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