Johan Winata1, Agnes L Panda, R Abdul Azis. 1. Cardiology and Vascular Medicine Department, Faculty of Medicine, University of Sam Ratulangi/Cardiovascular and Brain Center, RD Kandou General Hospital, Raya Tanawangko Street, Manado, North Sulawesi, Indonesia, winata.johan@gmail.com.
Abstract
BACKGROUND: In diabetes patients, albuminuria has been proven to be an independent predictor for SMI and delayed heart rate recovery (HRR). However, in hypertensive patients without diabetes the correlation is still unclear. AIM: To determine the correlation between albuminuria to SMI and delayed HRR in hypertensive patients without diabetes. METHODS: Fourty consecutive asymptomatic primary hypertensive men, aged 40-60 years, without diabetes were included. They underwent treadmill stress testing (TST) and collection of spot urine to measure albumin urine to creatinine ratio (ACR). SMI and HRR at first, second, and third minute were then recorded. SMI was diagnosed if positive ischemic criteria of TST was met without anginal symptom. Albuminuria and delayed HRR were diagnosed based on the treshold value respectively. RESULTS: SMI was diagnosed in 15 % patients. The prevalence of delayed HRR at the first-, second-, and third-minute after exercise were 60, 80, and 52.5 % respectively. Albuminuria was significantly associated with SMI [OR 13.889 (95 % CI 1.423-135.544), p = 0.014]. ROC curve analysis demonstrated the area under the curve (AUC) = 0.784 [(95 % CI 0.588-0.98), p = 0.028], with subsequent calculated sensitivity, specificity, positive- and negative-predictive value of albuminuria to predict SMI were 83.3, 73.5, 35.7, and 96.2 % respectively. Those were no significant correlation between albuminuria and delayed HRR at first, second, and third minute. CONCLUSION: Albuminuria is a potential marker for excluding SMI in asymptomatic hypertensive men without diabetes.
BACKGROUND: In diabetespatients, albuminuria has been proven to be an independent predictor for SMI and delayed heart rate recovery (HRR). However, in hypertensivepatients without diabetes the correlation is still unclear. AIM: To determine the correlation between albuminuria to SMI and delayed HRR in hypertensivepatients without diabetes. METHODS: Fourty consecutive asymptomatic primary hypertensivemen, aged 40-60 years, without diabetes were included. They underwent treadmill stress testing (TST) and collection of spot urine to measure albumin urine to creatinine ratio (ACR). SMI and HRR at first, second, and third minute were then recorded. SMI was diagnosed if positive ischemic criteria of TST was met without anginal symptom. Albuminuria and delayed HRR were diagnosed based on the treshold value respectively. RESULTS: SMI was diagnosed in 15 % patients. The prevalence of delayed HRR at the first-, second-, and third-minute after exercise were 60, 80, and 52.5 % respectively. Albuminuria was significantly associated with SMI [OR 13.889 (95 % CI 1.423-135.544), p = 0.014]. ROC curve analysis demonstrated the area under the curve (AUC) = 0.784 [(95 % CI 0.588-0.98), p = 0.028], with subsequent calculated sensitivity, specificity, positive- and negative-predictive value of albuminuria to predict SMI were 83.3, 73.5, 35.7, and 96.2 % respectively. Those were no significant correlation between albuminuria and delayed HRR at first, second, and third minute. CONCLUSION:Albuminuria is a potential marker for excluding SMI in asymptomatic hypertensivemen without diabetes.
Authors: P Palatini; G R Graniero; P Mormino; M Mattarei; F Sanzuol; G B Cignacco; S Gregori; G Garavelli; F Pegoraro; G Maraglino; A Bortolazzi; V Accurso; F Dorigatti; F Graniero; R Gelisio; R Businaro; O Vriz; M Dal Follo; A Camarotto; A C Pessina Journal: Am J Hypertens Date: 1996-04 Impact factor: 2.689
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