| Literature DB >> 25849865 |
Jongshin Kim1, Haiin Jo1, Hyowon Hong1, Min Hwan Kim1, Jin Man Kim1, June-Koo Lee1, Won Do Heo2, Joon Kim1.
Abstract
Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly understood. Here we show that the actin cytoskeleton remodelling controls ciliogenesis by regulating transcriptional coactivator YAP/TAZ as well as ciliary vesicle trafficking. Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation-mediated ciliogenesis. We also identify actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components. Our work provides new insights for understanding the link between actin dynamics and ciliogenesis.Entities:
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Year: 2015 PMID： 25849865 DOI： 10.1038/ncomms7781
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919