Literature DB >> 26045258

YAP and TAZ: a nexus for Hippo signaling and beyond.

Carsten Gram Hansen1,2, Toshiro Moroishi1,2, Kun-Liang Guan1,2.   

Abstract

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta (TGFβ), and Notch pathways.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Notch; Wnt; extracellular matrix; primary cilia; regeneration; stem cells

Mesh：

Substances：

Year:  2015        PMID： 26045258      PMCID： PMC4554827          DOI： 10.1016/j.tcb.2015.05.002

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


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