| Literature DB >> 25848691 |
Huaxia Luo1,2, Yu Sun1,2, Guifeng Wei1,2, Jianjun Luo1, Xinling Yang1,2,3, Wei Liu1,2, Mingzhou Guo4, Runsheng Chen1,5.
Abstract
Long noncoding RNAs (lncRNAs) are pervasively transcribed in the human genome. Recent studies suggest that the involvement of lncRNAs in human diseases could be far more prevalent than previously appreciated. Here we have identified a lncRNA termed Lnc_bc060912 whose expression is increased in human lung and other tumors. Lnc_bc060912 is 1.2 kb in length and is composed of two exons. The expression of Lnc_bc060912 was repressed by p53. Lnc_bc060912 suppressed cell apoptosis. Using a recently developed method for RNA-pulldown with formaldehyde cross-linking, we found that Lnc_bc060912 interacted with the two DNA damage repair proteins PARP1 and NPM1. Together, these results suggest that Lnc_bc060912, via PARP1 and NPM1, affects cell apoptosis and may play important roles in tumorigenesis and cancer progression.Entities:
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Year: 2015 PMID： 25848691 DOI： 10.1021/acs.biochem.5b00259
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162