Literature DB >> 25847629

Novel olfactory ligands via terpene synthases.

Sabrina Touchet1, Keith Chamberlain, Christine M Woodcock, David J Miller, Michael A Birkett, John A Pickett, Rudolf K Allemann.   

Abstract

A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

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Year:  2015        PMID： 25847629     DOI： 10.1039/c5cc01814e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

Review 1.  Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids.

Authors:  Alexandra A Malico; Miles A Calzini; Anuran K Gayen; Gavin J Williams
Journal:  J Ind Microbiol Biotechnol       Date:  2020-09-03       Impact factor: 3.346

Review 2.  Characterizing human odorant signals: insights from insect semiochemistry and in silico modelling.

Authors:  Ashish Radadiya; John A Pickett
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2020-04-20       Impact factor: 6.237

3.  Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase.

Authors:  Marianna Loizzi; David J Miller; Rudolf K Allemann
Journal:  Org Biomol Chem       Date:  2019-01-31       Impact factor: 3.876

4.  An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde.

Authors:  Melodi Demiray; Xiaoping Tang; Thomas Wirth; Juan A Faraldos; Rudolf K Allemann
Journal:  Angew Chem Int Ed Engl       Date:  2017-03-13       Impact factor: 15.336

5.  Concise synthesis of artemisinin from a farnesyl diphosphate analogue.

Authors:  Xiaoping Tang; Melodi Demiray; Thomas Wirth; Rudolf K Allemann
Journal:  Bioorg Med Chem       Date:  2017-04-04       Impact factor: 3.641

6.  Sesquiterpene Synthase-Catalysed Formation of a New Medium-Sized Cyclic Terpenoid Ether from Farnesyl Diphosphate Analogues.

Authors:  Florence Huynh; Daniel J Grundy; Robert L Jenkins; David J Miller; Rudolf K Allemann
Journal:  Chembiochem       Date:  2018-07-16       Impact factor: 3.164

7.  Removing constraints to sustainable food production: new ways to exploit secondary metabolism from companion planting and GM.

Authors:  John A Pickett; Charles Ao Midega; Jimmy Pittchar; Zeyaur R Khan
Journal:  Pest Manag Sci       Date:  2019-07-09       Impact factor: 4.845

8.  Optimising Terpene Synthesis with Flow Biocatalysis.

Authors:  Xiaoping Tang; Rudolf K Allemann; Thomas Wirth
Journal:  European J Org Chem       Date:  2017-01-13

9.  Nucleophilic Water Capture or Proton Loss: Single Amino Acid Switch Converts δ-Cadinene Synthase into Germacradien-4-ol Synthase.

Authors:  Marianna Loizzi; Veronica González; David J Miller; Rudolf K Allemann
Journal:  Chembiochem       Date:  2017-11-23       Impact factor: 3.164

Review 10.  Prospects for management of whitefly using plant semiochemicals, compared with related pests.

Authors:  Stefanie Schlaeger; John A Pickett; Michael A Birkett
Journal:  Pest Manag Sci       Date:  2018-06-13       Impact factor: 4.845
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