Literature DB >> 25841549

Anaphylaxis to the carbohydrate side chain alpha-gal.

Thomas A E Platts-Mills1, Alexander J Schuyler2, Anubha Tripathi2, Scott P Commins2.   

Abstract

In 2007, the monoclonal antibody cetuximab caused severe hypersensitivity reactions during the first infusion in a region of the southeastern United States. Investigation of pretreatment sera established that they contained immunoglobulin (Ig) E against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), which is present on the Fab of cetuximab. Alpha-gal is a blood group substance of nonprimate mammals. These IgE antibodies are also associated with delayed anaphylaxis to red meat (ie, to meat or organs of animals that carry this oligosaccharide). Evidence shows that the primary cause of these IgE antibodies is bites from the tick Amblyomma americanum or its larvae.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alpha-gal; Cetuximab; Delayed anaphylaxis; Red-meat allergy; Ticks

Mesh：

Substances：

Year:  2015        PMID： 25841549      PMCID： PMC4617526          DOI： 10.1016/j.iac.2015.01.009

Source DB:  PubMed          Journal:  Immunol Allergy Clin North Am        ISSN： 0889-8561            Impact factor:   3.479


  44 in total

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5.  Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose.

Authors:  Scott P Commins; Shama M Satinover; Jacob Hosen; Jonathan Mozena; Larry Borish; Barrett D Lewis; Judith A Woodfolk; Thomas A E Platts-Mills
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