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Literature DB >> 25837870

Structures of human DNA polymerases ν and θ expose their end game.

Abstract

Although the two B-family human DNA polymerases, pol δ and pol ε, are responsible for the bulk of nuclear genome replication, at least 14 additional polymerases have roles in nuclear DNA repair and replication. In this issue, newly reported crystal structures of two specialized A-family polymerases, pol δ and pol ε, expose these enzymes’ strategies for handling aberrant DNA ends.

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Year: 2015 PMID： 25837870 DOI： 10.1038/nsmb.3006

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

19 in total

1. Sequence-specific recognition of double helical nucleic acids by proteins.

Authors: N C Seeman; J M Rosenberg; A Rich
Journal: Proc Natl Acad Sci U S A Date: 1976-03 Impact factor: 11.205

2. Substrate-induced DNA polymerase β activation.

Authors: William A Beard; David D Shock; Vinod K Batra; Rajendra Prasad; Samuel H Wilson
Journal: J Biol Chem Date: 2014-09-26 Impact factor: 5.157

Review 3. Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site.

Authors: Sangwook Wu; William A Beard; Lee G Pedersen; Samuel H Wilson
Journal: Chem Rev Date: 2013-12-20 Impact factor: 60.622

Structures of human DNA polymerases ν and θ expose their end game.

1. Sequence-specific recognition of double helical nucleic acids by proteins.

2. Substrate-induced DNA polymerase β activation.

Review 3. Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site.

4. The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution.

5. Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links.

6. DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.

7. Promiscuous DNA synthesis by human DNA polymerase θ.

8. Human DNA polymerase θ grasps the primer terminus to mediate DNA repair.

9. How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.

10. Low-fidelity DNA synthesis by human DNA polymerase theta.

1. Expression and Structural Analyses of Human DNA Polymerase θ (POLQ).

Review 2. Structure and function relationships in mammalian DNA polymerases.

Review 3. DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol.

Review 4. Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.