Literature DB >> 25837820

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.

Ali Amin Al Olama1, Sara Benlloch2, Antonis C Antoniou2, Graham G Giles3, Gianluca Severi4, David E Neal5, Freddie C Hamdy6, Jenny L Donovan7, Kenneth Muir8, Johanna Schleutker9, Brian E Henderson10, Christopher A Haiman10, Fredrick R Schumacher10, Nora Pashayan11, Paul D P Pharoah2, Elaine A Ostrander12, Janet L Stanford13, Jyotsna Batra14, Judith A Clements14, Suzanne K Chambers15, Maren Weischer16, Børge G Nordestgaard16, Sue A Ingles10, Karina D Sorensen17, Torben F Orntoft17, Jong Y Park18, Cezary Cybulski19, Christiane Maier20, Thilo Doerk21, Joanne L Dickinson22, Lisa Cannon-Albright23, Hermann Brenner24, Timothy R Rebbeck25, Charnita Zeigler-Johnson26, Tomonori Habuchi27, Stephen N Thibodeau28, Kathleen A Cooney29, Pierre O Chappuis30, Pierre Hutter31, Radka P Kaneva32, William D Foulkes33, Maurice P Zeegers34, Yong-Jie Lu35, Hong-Wei Zhang36, Robert Stephenson37, Angela Cox38, Melissa C Southey39, Amanda B Spurdle40, Liesel FitzGerald41, Daniel Leongamornlert42, Edward Saunders42, Malgorzata Tymrakiewicz42, Michelle Guy42, Tokhir Dadaev42, Sarah J Little42, Koveela Govindasami42, Emma Sawyer42, Rosemary Wilkinson42, Kathleen Herkommer43, John L Hopper44, Aritaya Lophatonanon45, Antje E Rinckleb20, Zsofia Kote-Jarai42, Rosalind A Eeles, Douglas F Easton1.   

Abstract

BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their risk of prostate cancer.
METHODS: We genotyped 25 prostate cancer susceptibility loci in 40,414 individuals and derived a polygenic risk score (PRS). We estimated empirical odds ratios (OR) for prostate cancer associated with different risk strata defined by PRS and derived age-specific absolute risks of developing prostate cancer by PRS stratum and family history.
RESULTS: The prostate cancer risk for men in the top 1% of the PRS distribution was 30.6 (95% CI, 16.4-57.3) fold compared with men in the bottom 1%, and 4.2 (95% CI, 3.2-5.5) fold compared with the median risk. The absolute risk of prostate cancer by age of 85 years was 65.8% for a man with family history in the top 1% of the PRS distribution, compared with 3.7% for a man in the bottom 1%. The PRS was only weakly correlated with serum PSA level (correlation = 0.09).
CONCLUSIONS: Risk profiling can identify men at substantially increased or reduced risk of prostate cancer. The effect size, measured by OR per unit PRS, was higher in men at younger ages and in men with family history of prostate cancer. Incorporating additional newly identified loci into a PRS should improve the predictive value of risk profiles. IMPACT: We demonstrate that the risk profiling based on SNPs can identify men at substantially increased or reduced risk that could have useful implications for targeted prevention and screening programs. ©2015 American Association for Cancer Research.

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Year:  2015        PMID: 25837820      PMCID: PMC4491026          DOI: 10.1158/1055-9965.EPI-14-0317

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  22 in total

1.  Polygenic inheritance of breast cancer: Implications for design of association studies.

Authors:  Antonis C Antoniou; Douglas F Easton
Journal:  Genet Epidemiol       Date:  2003-11       Impact factor: 2.135

2.  Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study.

Authors:  A C Antoniou; P D Pharoah; G McMullan; N E Day; B A Ponder; D Easton
Journal:  Genet Epidemiol       Date:  2001-07       Impact factor: 2.135

3.  A common variant associated with prostate cancer in European and African populations.

Authors:  Laufey T Amundadottir; Patrick Sulem; Julius Gudmundsson; Agnar Helgason; Adam Baker; Bjarni A Agnarsson; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Jean-Baptiste Cazier; Jesus Sainz; Margret Jakobsdottir; Jelena Kostic; Droplaug N Magnusdottir; Shyamali Ghosh; Kari Agnarsson; Birgitta Birgisdottir; Louise Le Roux; Adalheidur Olafsdottir; Thorarinn Blondal; Margret Andresdottir; Olafia Svandis Gretarsdottir; Jon T Bergthorsson; Daniel Gudbjartsson; Arnaldur Gylfason; Gudmar Thorleifsson; Andrei Manolescu; Kristleifur Kristjansson; Gudmundur Geirsson; Helgi Isaksson; Julie Douglas; Jan-Erik Johansson; Katarina Bälter; Fredrik Wiklund; James E Montie; Xiaoying Yu; Brian K Suarez; Carole Ober; Kathleen A Cooney; Henrik Gronberg; William J Catalona; Gudmundur V Einarsson; Rosa B Barkardottir; Jeffrey R Gulcher; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Nat Genet       Date:  2006-05-07       Impact factor: 38.330

4.  Multiple regions within 8q24 independently affect risk for prostate cancer.

Authors:  Christopher A Haiman; Nick Patterson; Matthew L Freedman; Simon R Myers; Malcolm C Pike; Alicja Waliszewska; Julie Neubauer; Arti Tandon; Christine Schirmer; Gavin J McDonald; Steven C Greenway; Daniel O Stram; Loic Le Marchand; Laurence N Kolonel; Melissa Frasco; David Wong; Loreall C Pooler; Kristin Ardlie; Ingrid Oakley-Girvan; Alice S Whittemore; Kathleen A Cooney; Esther M John; Sue A Ingles; David Altshuler; Brian E Henderson; David Reich
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

5.  Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.

Authors:  Julius Gudmundsson; Patrick Sulem; Valgerdur Steinthorsdottir; Jon T Bergthorsson; Gudmar Thorleifsson; Andrei Manolescu; Thorunn Rafnar; Daniel Gudbjartsson; Bjarni A Agnarsson; Adam Baker; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Margret Jakobsdottir; Thorarinn Blondal; Simon N Stacey; Agnar Helgason; Steinunn Gunnarsdottir; Adalheidur Olafsdottir; Kari T Kristinsson; Birgitta Birgisdottir; Shyamali Ghosh; Steinunn Thorlacius; Dana Magnusdottir; Gerdur Stefansdottir; Kristleifur Kristjansson; Yu Bagger; Robert L Wilensky; Muredach P Reilly; Andrew D Morris; Charlotte H Kimber; Adebowale Adeyemo; Yuanxiu Chen; Jie Zhou; Wing-Yee So; Peter C Y Tong; Maggie C Y Ng; Torben Hansen; Gitte Andersen; Knut Borch-Johnsen; Torben Jorgensen; Alejandro Tres; Fernando Fuertes; Manuel Ruiz-Echarri; Laura Asin; Berta Saez; Erica van Boven; Siem Klaver; Dorine W Swinkels; Katja K Aben; Theresa Graif; John Cashy; Brian K Suarez; Onco van Vierssen Trip; Michael L Frigge; Carole Ober; Marten H Hofker; Cisca Wijmenga; Claus Christiansen; Daniel J Rader; Colin N A Palmer; Charles Rotimi; Juliana C N Chan; Oluf Pedersen; Gunnar Sigurdsson; Rafn Benediktsson; Eirikur Jonsson; Gudmundur V Einarsson; Jose I Mayordomo; William J Catalona; Lambertus A Kiemeney; Rosa B Barkardottir; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2007-07-01       Impact factor: 38.330

6.  Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Authors:  Julius Gudmundsson; Patrick Sulem; Andrei Manolescu; Laufey T Amundadottir; Daniel Gudbjartsson; Agnar Helgason; Thorunn Rafnar; Jon T Bergthorsson; Bjarni A Agnarsson; Adam Baker; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Margret Jakobsdottir; Jianfeng Xu; Thorarinn Blondal; Jelena Kostic; Jielin Sun; Shyamali Ghosh; Simon N Stacey; Magali Mouy; Jona Saemundsdottir; Valgerdur M Backman; Kristleifur Kristjansson; Alejandro Tres; Alan W Partin; Marjo T Albers-Akkers; Javier Godino-Ivan Marcos; Patrick C Walsh; Dorine W Swinkels; Sebastian Navarrete; Sarah D Isaacs; Katja K Aben; Theresa Graif; John Cashy; Manuel Ruiz-Echarri; Kathleen E Wiley; Brian K Suarez; J Alfred Witjes; Mike Frigge; Carole Ober; Eirikur Jonsson; Gudmundur V Einarsson; Jose I Mayordomo; Lambertus A Kiemeney; William B Isaacs; William J Catalona; Rosa B Barkardottir; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

7.  Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies.

Authors:  Robert J MacInnis; Antonis C Antoniou; Rosalind A Eeles; Gianluca Severi; Michelle Guy; Lesley McGuffog; Amanda L Hall; Lynne T O'Brien; Rosemary A Wilkinson; David P Dearnaley; Audrey T Ardern-Jones; Alan Horwich; Vincent S Khoo; Christopher C Parker; Robert A Huddart; Margaret R McCredie; Charmaine Smith; Melissa C Southey; Margaret P Staples; Dallas R English; John L Hopper; Graham G Giles; Douglas F Easton
Journal:  Genet Epidemiol       Date:  2010-01       Impact factor: 2.135

8.  Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

Authors:  Rosalind A Eeles; Zsofia Kote-Jarai; Ali Amin Al Olama; Graham G Giles; Michelle Guy; Gianluca Severi; Kenneth Muir; John L Hopper; Brian E Henderson; Christopher A Haiman; Johanna Schleutker; Freddie C Hamdy; David E Neal; Jenny L Donovan; Janet L Stanford; Elaine A Ostrander; Sue A Ingles; Esther M John; Stephen N Thibodeau; Daniel Schaid; Jong Y Park; Amanda Spurdle; Judith Clements; Joanne L Dickinson; Christiane Maier; Walther Vogel; Thilo Dörk; Timothy R Rebbeck; Kathleen A Cooney; Lisa Cannon-Albright; Pierre O Chappuis; Pierre Hutter; Maurice Zeegers; Radka Kaneva; Hong-Wei Zhang; Yong-Jie Lu; William D Foulkes; Dallas R English; Daniel A Leongamornlert; Malgorzata Tymrakiewicz; Jonathan Morrison; Audrey T Ardern-Jones; Amanda L Hall; Lynne T O'Brien; Rosemary A Wilkinson; Edward J Saunders; Elizabeth C Page; Emma J Sawyer; Stephen M Edwards; David P Dearnaley; Alan Horwich; Robert A Huddart; Vincent S Khoo; Christopher C Parker; Nicholas Van As; Christopher J Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Colin S Cooper; Melissa C Southey; Artitaya Lophatananon; Jo-Fen Liu; Laurence N Kolonel; Loic Le Marchand; Tiina Wahlfors; Teuvo L Tammela; Anssi Auvinen; Sarah J Lewis; Angela Cox; Liesel M FitzGerald; Joseph S Koopmeiners; Danielle M Karyadi; Erika M Kwon; Mariana C Stern; Roman Corral; Amit D Joshi; Ahva Shahabi; Shannon K McDonnell; Thomas A Sellers; Julio Pow-Sang; Suzanne Chambers; Joanne Aitken; R A Frank Gardiner; Jyotsna Batra; Mary Anne Kedda; Felicity Lose; Andrea Polanowski; Briony Patterson; Jürgen Serth; Andreas Meyer; Manuel Luedeke; Klara Stefflova; Anna M Ray; Ethan M Lange; Jim Farnham; Humera Khan; Chavdar Slavov; Atanaska Mitkova; Guangwen Cao; Douglas F Easton
Journal:  Nat Genet       Date:  2009-09-20       Impact factor: 38.330

9.  Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.

Authors:  Jacques Ferlay; Isabelle Soerjomataram; Rajesh Dikshit; Sultan Eser; Colin Mathers; Marise Rebelo; Donald Maxwell Parkin; David Forman; Freddie Bray
Journal:  Int J Cancer       Date:  2014-10-09       Impact factor: 7.396

10.  Multiple loci identified in a genome-wide association study of prostate cancer.

Authors:  Gilles Thomas; Kevin B Jacobs; Meredith Yeager; Peter Kraft; Sholom Wacholder; Nick Orr; Kai Yu; Nilanjan Chatterjee; Robert Welch; Amy Hutchinson; Andrew Crenshaw; Geraldine Cancel-Tassin; Brian J Staats; Zhaoming Wang; Jesus Gonzalez-Bosquet; Jun Fang; Xiang Deng; Sonja I Berndt; Eugenia E Calle; Heather Spencer Feigelson; Michael J Thun; Carmen Rodriguez; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Edward Giovannucci; Walter C Willett; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Margaret Tucker; Daniela S Gerhard; Joseph F Fraumeni; Robert Hoover; Richard B Hayes; David J Hunter; Stephen J Chanock
Journal:  Nat Genet       Date:  2008-02-10       Impact factor: 38.330

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  31 in total

1.  Differences in inherited risk among relatives of hereditary prostate cancer patients using genetic risk score.

Authors:  Brian T Helfand; Haitao Chen; Richard J Fantus; Carly A Conran; Charles B Brendler; Siquan Lilly Zheng; Patrick C Walsh; William B Isaacs; Jianfeng Xu
Journal:  Prostate       Date:  2018-06-19       Impact factor: 4.104

2.  SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns.

Authors:  Hui-Yi Lin; Dung-Tsa Chen; Po-Yu Huang; Yung-Hsin Liu; Augusto Ochoa; Jovanny Zabaleta; Donald E Mercante; Zhide Fang; Thomas A Sellers; Julio M Pow-Sang; Chia-Ho Cheng; Rosalind Eeles; Doug Easton; Zsofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch; Kenneth Muir; Graham G Giles; Fredrik Wiklund; Henrik Gronberg; Christopher A Haiman; Johanna Schleutker; Børge G Nordestgaard; Ruth C Travis; Freddie Hamdy; Nora Pashayan; Kay-Tee Khaw; Janet L Stanford; William J Blot; Stephen N Thibodeau; Christiane Maier; Adam S Kibel; Cezary Cybulski; Lisa Cannon-Albright; Hermann Brenner; Radka Kaneva; Jyotsna Batra; Manuel R Teixeira; Hardev Pandha; Yong-Jie Lu; Jong Y Park
Journal:  Bioinformatics       Date:  2017-03-15       Impact factor: 6.937

Review 3.  Precision Medicine and Men's Health.

Authors:  Douglas A Mata; Farhan M Katchi; Ranjith Ramasamy
Journal:  Am J Mens Health       Date:  2015-07-17

4.  Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer.

Authors:  Yanru Wang; Jennifer A Freedman; Hongliang Liu; Patricia G Moorman; Terry Hyslop; Daniel J George; Norman H Lee; Steven R Patierno; Qingyi Wei
Journal:  Int J Cancer       Date:  2017-06-01       Impact factor: 7.396

5.  Reclassification of prostate cancer risk using sequentially identified SNPs: Results from the REDUCE trial.

Authors:  Haitao Chen; Rong Na; Vignesh T Packiam; Carly A Conran; Deke Jiang; Sha Tao; Hongjie Yu; Xiaoling Lin; Wei Meng; S Lilly Zheng; Charles B Brendler; Brian T Helfand; Jianfeng Xu
Journal:  Prostate       Date:  2017-07-02       Impact factor: 4.104

6.  Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:  Fredrick R Schumacher; Ali Amin Al Olama; Sonja I Berndt; Sara Benlloch; Mahbubl Ahmed; Edward J Saunders; Tokhir Dadaev; Daniel Leongamornlert; Ezequiel Anokian; Clara Cieza-Borrella; Chee Goh; Mark N Brook; Xin Sheng; Laura Fachal; Joe Dennis; Jonathan Tyrer; Kenneth Muir; Artitaya Lophatananon; Victoria L Stevens; Susan M Gapstur; Brian D Carter; Catherine M Tangen; Phyllis J Goodman; Ian M Thompson; Jyotsna Batra; Suzanne Chambers; Leire Moya; Judith Clements; Lisa Horvath; Wayne Tilley; Gail P Risbridger; Henrik Gronberg; Markus Aly; Tobias Nordström; Paul Pharoah; Nora Pashayan; Johanna Schleutker; Teuvo L J Tammela; Csilla Sipeky; Anssi Auvinen; Demetrius Albanes; Stephanie Weinstein; Alicja Wolk; Niclas Håkansson; Catharine M L West; Alison M Dunning; Neil Burnet; Lorelei A Mucci; Edward Giovannucci; Gerald L Andriole; Olivier Cussenot; Géraldine Cancel-Tassin; Stella Koutros; Laura E Beane Freeman; Karina Dalsgaard Sorensen; Torben Falck Orntoft; Michael Borre; Lovise Maehle; Eli Marie Grindedal; David E Neal; Jenny L Donovan; Freddie C Hamdy; Richard M Martin; Ruth C Travis; Tim J Key; Robert J Hamilton; Neil E Fleshner; Antonio Finelli; Sue Ann Ingles; Mariana C Stern; Barry S Rosenstein; Sarah L Kerns; Harry Ostrer; Yong-Jie Lu; Hong-Wei Zhang; Ninghan Feng; Xueying Mao; Xin Guo; Guomin Wang; Zan Sun; Graham G Giles; Melissa C Southey; Robert J MacInnis; Liesel M FitzGerald; Adam S Kibel; Bettina F Drake; Ana Vega; Antonio Gómez-Caamaño; Robert Szulkin; Martin Eklund; Manolis Kogevinas; Javier Llorca; Gemma Castaño-Vinyals; Kathryn L Penney; Meir Stampfer; Jong Y Park; Thomas A Sellers; Hui-Yi Lin; Janet L Stanford; Cezary Cybulski; Dominika Wokolorczyk; Jan Lubinski; Elaine A Ostrander; Milan S Geybels; Børge G Nordestgaard; Sune F Nielsen; Maren Weischer; Rasmus Bisbjerg; Martin Andreas Røder; Peter Iversen; Hermann Brenner; Katarina Cuk; Bernd Holleczek; Christiane Maier; Manuel Luedeke; Thomas Schnoeller; Jeri Kim; Christopher J Logothetis; Esther M John; Manuel R Teixeira; Paula Paulo; Marta Cardoso; Susan L Neuhausen; Linda Steele; Yuan Chun Ding; Kim De Ruyck; Gert De Meerleer; Piet Ost; Azad Razack; Jasmine Lim; Soo-Hwang Teo; Daniel W Lin; Lisa F Newcomb; Davor Lessel; Marija Gamulin; Tomislav Kulis; Radka Kaneva; Nawaid Usmani; Sandeep Singhal; Chavdar Slavov; Vanio Mitev; Matthew Parliament; Frank Claessens; Steven Joniau; Thomas Van den Broeck; Samantha Larkin; Paul A Townsend; Claire Aukim-Hastie; Manuela Gago-Dominguez; Jose Esteban Castelao; Maria Elena Martinez; Monique J Roobol; Guido Jenster; Ron H N van Schaik; Florence Menegaux; Thérèse Truong; Yves Akoli Koudou; Jianfeng Xu; Kay-Tee Khaw; Lisa Cannon-Albright; Hardev Pandha; Agnieszka Michael; Stephen N Thibodeau; Shannon K McDonnell; Daniel J Schaid; Sara Lindstrom; Constance Turman; Jing Ma; David J Hunter; Elio Riboli; Afshan Siddiq; Federico Canzian; Laurence N Kolonel; Loic Le Marchand; Robert N Hoover; Mitchell J Machiela; Zuxi Cui; Peter Kraft; Christopher I Amos; David V Conti; Douglas F Easton; Fredrik Wiklund; Stephen J Chanock; Brian E Henderson; Zsofia Kote-Jarai; Christopher A Haiman; Rosalind A Eeles
Journal:  Nat Genet       Date:  2018-06-11       Impact factor: 38.330

7.  Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT.

Authors:  Freddie C Hamdy; Jenny L Donovan; J Athene Lane; Malcolm Mason; Chris Metcalfe; Peter Holding; Julia Wade; Sian Noble; Kirsty Garfield; Grace Young; Michael Davis; Tim J Peters; Emma L Turner; Richard M Martin; Jon Oxley; Mary Robinson; John Staffurth; Eleanor Walsh; Jane Blazeby; Richard Bryant; Prasad Bollina; James Catto; Andrew Doble; Alan Doherty; David Gillatt; Vincent Gnanapragasam; Owen Hughes; Roger Kockelbergh; Howard Kynaston; Alan Paul; Edgar Paez; Philip Powell; Stephen Prescott; Derek Rosario; Edward Rowe; David Neal
Journal:  Health Technol Assess       Date:  2020-08       Impact factor: 4.014

8.  Synergistic Interaction of HOXB13 and CIP2A Predisposes to Aggressive Prostate Cancer.

Authors:  Csilla Sipeky; Ping Gao; Qin Zhang; Liang Wang; Otto Ettala; Kirsi M Talala; Teuvo L J Tammela; Anssi Auvinen; Fredrik Wiklund; Gong-Hong Wei; Johanna Schleutker
Journal:  Clin Cancer Res       Date:  2018-09-04       Impact factor: 12.531

9.  Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.

Authors:  Karoline B Kuchenbaecker; Lesley McGuffog; Daniel Barrowdale; Andrew Lee; Penny Soucy; Joe Dennis; Susan M Domchek; Mark Robson; Amanda B Spurdle; Susan J Ramus; Nasim Mavaddat; Mary Beth Terry; Susan L Neuhausen; Rita Katharina Schmutzler; Jacques Simard; Paul D P Pharoah; Kenneth Offit; Fergus J Couch; Georgia Chenevix-Trench; Douglas F Easton; Antonis C Antoniou
Journal:  J Natl Cancer Inst       Date:  2017-07-01       Impact factor: 13.506

10.  Risk Analysis of Prostate Cancer in PRACTICAL Consortium--Response.

Authors:  Ali Amin Al Olama; Rosalind A Eeles; Zsofia Kote-Jarai; Douglas F Easton
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-01       Impact factor: 4.254

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