Literature DB >> 25836763

Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease.

Jonathan A R Gordon1, Janet L Stein2, Jennifer J Westendorf3, Andre J van Wijnen4.   

Abstract

Post-translational modifications of chromatin such as DNA methylation and different types of histone acetylation, methylation and phosphorylation are well-appreciated epigenetic mechanisms that confer information to progeny cells during lineage commitment. These distinct epigenetic modifications have defined roles in bone, development, tissue regeneration, cell commitment and differentiation, as well as disease etiologies. In this review, we discuss the role of these chromatin modifications and the enzymes regulating these marks (methyltransferases, demethylases, acetyltransferases, and deacetylases) in progenitor cells, osteoblasts and bone-related cells. In addition, the clinical relevance of deregulated histone modifications and enzymes as well as current and potential therapeutic interventions targeting chromatin modifiers are addressed.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Acetylation; Chromatin; Chromatin-modifiers; Epigenetics; Methylation; Osteogenic lineage cells

Mesh：

Substances：

Year:  2015        PMID： 25836763      PMCID： PMC4591092          DOI： 10.1016/j.bone.2015.03.011

Source DB:  PubMed          Journal:  Bone        ISSN： 1873-2763            Impact factor:   4.398


  114 in total

1.  Epigenetic mechanisms of Rubinstein-Taybi syndrome.

Authors:  Elizabeth Park; Yunha Kim; Hyun Ryu; Neil W Kowall; Junghee Lee; Hoon Ryu
Journal:  Neuromolecular Med       Date:  2014-01-01       Impact factor: 3.843

2.  EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification.

Authors:  Sarah Hemming; Dimitrios Cakouros; Sandra Isenmann; Lachlan Cooper; Danijela Menicanin; Andrew Zannettino; Stan Gronthos
Journal:  Stem Cells       Date:  2014-03       Impact factor: 6.277

3.  Reversing DNA methylation: mechanisms, genomics, and biological functions.

Authors:  Hao Wu; Yi Zhang
Journal:  Cell       Date:  2014-01-16       Impact factor: 41.582

4.  Sirt1-deficient mice exhibit an altered cartilage phenotype.

Authors:  Odile Gabay; Kristien J Zaal; Christelle Sanchez; Mona Dvir-Ginzberg; Viktoria Gagarina; Yingjie Song; Xiao Hong He; Michael W McBurney
Journal:  Joint Bone Spine       Date:  2013-04-13       Impact factor: 4.929

5.  Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation.

Authors:  Hanna Oppenheimer; Ashok Kumar; Hadar Meir; Israel Schwartz; Avi Zini; Amir Haze; Leonid Kandel; Yoav Mattan; Meir Liebergall; Mona Dvir-Ginzberg
Journal:  J Bone Miner Res       Date:  2014-02       Impact factor: 6.741

6.  Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and osterix.

Authors:  Di Yang; Hirohiko Okamura; Yoshiki Nakashima; Tatsuji Haneji
Journal:  J Biol Chem       Date:  2013-10-08       Impact factor: 5.157

7.  Ezh2 is required for neural crest-derived cartilage and bone formation.

Authors:  Daniel Schwarz; Sandra Varum; Martina Zemke; Anne Schöler; Arianna Baggiolini; Kalina Draganova; Haruhiko Koseki; Dirk Schübeler; Lukas Sommer
Journal:  Development       Date:  2014-02       Impact factor: 6.868

Review 8.  Emerging epigenetic mechanisms of long non-coding RNAs.

Authors:  K Schaukowitch; T-K Kim
Journal:  Neuroscience       Date:  2013-12-14       Impact factor: 3.590

9.  Separate and combined effects of DNMT and HDAC inhibitors in treating human multi-drug resistant osteosarcoma HosDXR150 cell line.

Authors:  Enrico Capobianco; Antonio Mora; Dario La Sala; Annalisa Roberti; Nazar Zaki; Elarbi Badidi; Monia Taranta; Caterina Cinti
Journal:  PLoS One       Date:  2014-04-22       Impact factor: 3.240

10.  Histone deacetylase inhibition with valproic acid downregulates osteocalcin gene expression in human dental pulp stem cells and osteoblasts: evidence for HDAC2 involvement.

Authors:  Francesca Paino; Marcella La Noce; Virginia Tirino; Pasqualina Naddeo; Vincenzo Desiderio; Giuseppe Pirozzi; Alfredo De Rosa; Luigi Laino; Lucia Altucci; Gianpaolo Papaccio
Journal:  Stem Cells       Date:  2014-01       Impact factor: 6.277
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  30 in total

1.  Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate.

Authors:  Roman Thaler; Antonio Maurizi; Paul Roschger; Ines Sturmlechner; Farzaneh Khani; Silvia Spitzer; Monika Rumpler; Jochen Zwerina; Heidrun Karlic; Amel Dudakovic; Klaus Klaushofer; Anna Teti; Nadia Rucci; Franz Varga; Andre J van Wijnen
Journal:  J Biol Chem       Date:  2016-01-12       Impact factor: 5.157

2.  Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis.

Authors:  Hai Wu; Jonathan A R Gordon; Troy W Whitfield; Phillip W L Tai; Andre J van Wijnen; Janet L Stein; Gary S Stein; Jane B Lian
Journal:  Biochim Biophys Acta Gene Regul Mech       Date:  2017-01-08       Impact factor: 4.490

3.  PTH Signaling and Epigenetic Control of Bone Remodeling.

Authors:  Florante Ricarte; Teruyo Nakatani; Nicola Partridge
Journal:  Curr Mol Biol Rep       Date:  2016-02-03

4.  Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development.

Authors:  Emily T Camilleri; Amel Dudakovic; Scott M Riester; Catalina Galeano-Garces; Christopher R Paradise; Elizabeth W Bradley; Meghan E McGee-Lawrence; Hee-Jeong Im; Marcel Karperien; Aaron J Krych; Jennifer J Westendorf; A Noelle Larson; Andre J van Wijnen
Journal:  J Biol Chem       Date:  2018-10-16       Impact factor: 5.157

Review 5.  Molecular genetics of osteosarcoma.

Authors:  Kirby Rickel; Fang Fang; Jianning Tao
Journal:  Bone       Date:  2016-10-17       Impact factor: 4.398

6.  Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.

Authors:  Farzaneh Khani; Roman Thaler; Christopher R Paradise; David R Deyle; Marianne Kruijthof-de Julio; Mario Galindo; Jonathan A Gordon; Gary S Stein; Amel Dudakovic; Andre J van Wijnen
Journal:  J Cell Biochem       Date:  2016-11-30       Impact factor: 4.429

7.  Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice.

Authors:  Amel Dudakovic; Emily T Camilleri; Scott M Riester; Christopher R Paradise; Martina Gluscevic; Thomas M O'Toole; Roman Thaler; Jared M Evans; Huihuang Yan; Malayannan Subramaniam; John R Hawse; Gary S Stein; Martin A Montecino; Meghan E McGee-Lawrence; Jennifer J Westendorf; Andre J van Wijnen
Journal:  J Biol Chem       Date:  2016-10-10       Impact factor: 5.157

8.  Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.

Authors:  Lomeli R Carpio; Elizabeth W Bradley; Meghan E McGee-Lawrence; Megan M Weivoda; Daniel D Poston; Amel Dudakovic; Ming Xu; Tamar Tchkonia; James L Kirkland; Andre J van Wijnen; Merry Jo Oursler; Jennifer J Westendorf
Journal:  Sci Signal       Date:  2016-08-09       Impact factor: 8.192

9.  Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8.

Authors:  Celestia Fang; Yu Qiao; Kyung-Hyun Park-Min; Lionel B Ivashkiv; Se Hwan Mun; Min Joon Lee; Koichi Murata; Seyeon Bae; Baohong Zhao
Journal:  J Immunol       Date:  2016-04-29       Impact factor: 5.422

10.  Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone.

Authors:  Endre Soreide; Janet M Denbeigh; Eric A Lewallen; Rebekah M Samsonraj; Lawrence J Berglund; Amel Dudakovic; Simon M Cool; Lars Nordsletten; Sanjeev Kakar; Andre J van Wijnen
Journal:  J Cell Biochem       Date:  2018-03-25       Impact factor: 4.429
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