| Literature DB >> 25833720 |
Chul Won Ahn1, Do Young Kwon, Doo Sung Jun, Yoo Min Lee, Young Chul Kim.
Abstract
We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were significantly higher than those found in the saline-treated rats. It is therefore suggested that enhancement of cysteine catabolism into taurine contributes to the depletion of hepatic glutathione, which could exacerbate the ethanol-induced oxidative liver injury.Entities:
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Year: 2015 PMID： 25833720 DOI： 10.1007/s00726-015-1969-2
Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520