Literature DB >> 25832051

Comparison of film measurements and Monte Carlo simulations of dose delivered with very high-energy electron beams in a polystyrene phantom.

Magdalena Bazalova-Carter1, Michael Liu1, Bianey Palma1, Michael Dunning2, Doug McCormick2, Erik Hemsing2, Janice Nelson2, Keith Jobe2, Eric Colby2, Albert C Koong1, Sami Tantawi2, Valery Dolgashev2, Peter G Maxim1, Billy W Loo1.   

Abstract

PURPOSE: To measure radiation dose in a water-equivalent medium from very high-energy electron (VHEE) beams and make comparisons to Monte Carlo (MC) simulation results.
METHODS: Dose in a polystyrene phantom delivered by an experimental VHEE beam line was measured with Gafchromic films for three 50 MeV and two 70 MeV Gaussian beams of 4.0-6.9 mm FWHM and compared to corresponding MC-simulated dose distributions. MC dose in the polystyrene phantom was calculated with the EGSnrc/BEAMnrc and DOSXYZnrc codes based on the experimental setup. Additionally, the effect of 2% beam energy measurement uncertainty and possible non-zero beam angular spread on MC dose distributions was evaluated.
RESULTS: MC simulated percentage depth dose (PDD) curves agreed with measurements within 4% for all beam sizes at both 50 and 70 MeV VHEE beams. Central axis PDD at 8 cm depth ranged from 14% to 19% for the 5.4-6.9 mm 50 MeV beams and it ranged from 14% to 18% for the 4.0-4.5 mm 70 MeV beams. MC simulated relative beam profiles of regularly shaped Gaussian beams evaluated at depths of 0.64 to 7.46 cm agreed with measurements to within 5%. A 2% beam energy uncertainty and 0.286° beam angular spread corresponded to a maximum 3.0% and 3.8% difference in depth dose curves of the 50 and 70 MeV electron beams, respectively. Absolute dose differences between MC simulations and film measurements of regularly shaped Gaussian beams were between 10% and 42%.
CONCLUSIONS: The authors demonstrate that relative dose distributions for VHEE beams of 50-70 MeV can be measured with Gafchromic films and modeled with Monte Carlo simulations to an accuracy of 5%. The reported absolute dose differences likely caused by imperfect beam steering and subsequent charge loss revealed the importance of accurate VHEE beam control and diagnostics.

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Year:  2015        PMID: 25832051     DOI: 10.1118/1.4914371

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  6 in total

1.  Optimization of an on-board imaging system for extremely rapid radiation therapy.

Authors:  Erica M Cherry Kemmerling; Meng Wu; He Yang; Peter G Maxim; Billy W Loo; Rebecca Fahrig
Journal:  Med Phys       Date:  2015-11       Impact factor: 4.071

Review 2.  Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm.

Authors:  Emil Schüler; Munjal Acharya; Pierre Montay-Gruel; Billy W Loo; Marie-Catherine Vozenin; Peter G Maxim
Journal:  Med Phys       Date:  2022-01-19       Impact factor: 4.506

3.  Initial Steps Towards a Clinical FLASH Radiotherapy System: Pediatric Whole Brain Irradiation with 40 MeV Electrons at FLASH Dose Rates.

Authors:  Dylan Yamabe Breitkreutz; Muhammad Shumail; Karl K Bush; Sami G Tantawi; Peter G Maxime; Billy W Loo
Journal:  Radiat Res       Date:  2020-12-01       Impact factor: 2.841

Review 4.  Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Authors:  Joseph D Wilson; Ester M Hammond; Geoff S Higgins; Kristoffer Petersson
Journal:  Front Oncol       Date:  2020-01-17       Impact factor: 6.244

5.  Determination of the ion collection efficiency of the Razor Nano Chamber for ultra-high dose-rate electron beams.

Authors:  Marco Cavallone; Patrik Gonçalves Jorge; Raphaël Moeckli; Claude Bailat; Alessandro Flacco; Yolanda Prezado; Rachel Delorme
Journal:  Med Phys       Date:  2022-05-20       Impact factor: 4.506

6.  Monte Carlo simulations of EBT3 film dose deposition for percentage depth dose (PDD) curve evaluation.

Authors:  Spencer M Robinson; Nolan Esplen; Derek Wells; Magdalena Bazalova-Carter
Journal:  J Appl Clin Med Phys       Date:  2020-11-06       Impact factor: 2.102

  6 in total

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