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Literature DB >> 2583101

Head activator acts as an autocrine growth factor for NH15-CA2 cells in the G2/mitosis transition.

H C Schaller¹, S Druffel-Augustin, S Dübel.

Abstract

The neuropeptide head activator (HA) acts as an autocrine growth factor for the neural cell line NH15-CA2. Cell proliferation is increased in the presence of HA and inhibited by HA peptide-specific antisera. Stimulation of cellular proliferation is visible 2 h after HA application as an increase in cells in mitosis. HA has no direct effect on stimulating DNA synthesis. HA thus functions as a control signal in the G2/mitosis transition and not in the G1/S transition. Receptors for HA are present on small round cells in clusters of foci and not on cells with differentiated morphology, suggesting cell-cycle-dependent HA receptor expression.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2583101 PMCID： PMC401466 DOI： 10.1002/j.1460-2075.1989.tb08492.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

20 in total

1. Cyclin synthesis drives the early embryonic cell cycle.

Authors: A W Murray; M W Kirschner
Journal: Nature Date: 1989-05-25 Impact factor: 49.962

Review 2. Cell cycle control genes in fission yeast and mammalian cells.

Authors: M Lee; P Nurse
Journal: Trends Genet Date: 1988-10 Impact factor: 11.639

3. Genetic control of cell division patterns in the Drosophila embryo.

Authors: B A Edgar; P H O'Farrell
Journal: Cell Date: 1989-04-07 Impact factor: 41.582

Review 4. Ninth Adolf Butenandt lecture. Role of the neuropeptide head activator for nerve function and development.

Authors: H C Schaller; H Bodenmüller
Journal: Biol Chem Hoppe Seyler Date: 1985-11

5. A rapid method for accurate DNA measurements in single cells in situ using a simple microfluorimeter and Hoechst 33258 as a quantitative fluorochrome.

Authors: J K Cowell; L M Franks
Journal: J Histochem Cytochem Date: 1980-03 Impact factor: 2.479

1. cDNA sequence and genomic characterization of intracisternal A-particle-related retroviral elements containing an envelope gene.

Authors: F U Reuss; H C Schaller
Journal: J Virol Date: 1991-11 Impact factor: 5.103

2. Terminal differentiation of ectodermal epithelial stem cells of Hydra can occur in G2 without requiring mitosis or S phase.

Authors: S Dübel; H C Schaller
Journal: J Cell Biol Date: 1990-04 Impact factor: 10.539

2 in total

Head activator acts as an autocrine growth factor for NH15-CA2 cells in the G2/mitosis transition.

1. Cyclin synthesis drives the early embryonic cell cycle.

Review 2. Cell cycle control genes in fission yeast and mammalian cells.

3. Genetic control of cell division patterns in the Drosophila embryo.

Review 4. Ninth Adolf Butenandt lecture. Role of the neuropeptide head activator for nerve function and development.

5. A rapid method for accurate DNA measurements in single cells in situ using a simple microfluorimeter and Hoechst 33258 as a quantitative fluorochrome.

6. A mitotic inducer matures.

7. Enzyme-linked immunosorbent assay for the neuropeptide 'head activator'.

8. Conserved amino acid sequence of a neuropeptide, the head activator, from coelenterates to humans.

9. The head activator is released from regenerating Hydra bound to a carrier molecule.

10. Cell cycle kinetics and development of Hydra attenuata. I. Epithelial cells.

1. cDNA sequence and genomic characterization of intracisternal A-particle-related retroviral elements containing an envelope gene.

2. Terminal differentiation of ectodermal epithelial stem cells of Hydra can occur in G2 without requiring mitosis or S phase.