Literature DB >> 25829758

Achondroplasia and limb lengthening: Results in a UK cohort and review of the literature.

James Donaldson1, Syed Aftab1, Christopher Bradish1.   

Abstract

AIMS: We aim to review the results, complications and outcomes of a single surgeon's series of lower limb lengthening in patients with achondroplasia.
METHODS: Ten achondroplastic children underwent limb lengthening. The patients, medical records and radiographs were reviewed.
RESULTS: The average age at the time of the index operation was 7.8 years. A single surgeon undertook all procedures. The average total length gain was 20.5 cm. The commonest complication was a fractured femur after removal of the frame.
CONCLUSION: Although complication rates were high (70%), none were left with any long-term sequelae and all were pleased with the results.

Entities:  

Keywords:  Achondroplasia; Distraction osteogenesis; Limb lengthening

Year:  2015        PMID: 25829758      PMCID: PMC4353991          DOI: 10.1016/j.jor.2015.01.001

Source DB:  PubMed          Journal:  J Orthop        ISSN: 0972-978X


  17 in total

1.  Attempted limb lengthenings beyond twenty percent of the initial bone length: results and complications.

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Journal:  J Pediatr Orthop       Date:  2000 Mar-Apr       Impact factor: 2.324

2.  Response of the physis to leg lengthening.

Authors:  S H Lee; G Szöke; H Simpson
Journal:  J Pediatr Orthop B       Date:  2001-10       Impact factor: 1.041

3.  Growth disturbance after lengthening of the lower limb and quantitative assessment of physeal closure in skeletally immature patients with achondroplasia.

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4.  Complications of Ilizarov leg lengthening: a comparative study between patients with leg length discrepancy and short stature.

Authors:  B Vargas Barreto; J Caton; Z Merabet; J C Panisset; J P Pracros
Journal:  Int Orthop       Date:  2006-10-12       Impact factor: 3.075

Review 5.  Advances in understanding etiology of achondroplasia and review of management.

Authors:  Erin M Carter; Jessica G Davis; Cathleen L Raggio
Journal:  Curr Opin Pediatr       Date:  2007-02       Impact factor: 2.856

Review 6.  Clinical application of the tension-stress effect for limb lengthening.

Authors:  G A Ilizarov
Journal:  Clin Orthop Relat Res       Date:  1990-01       Impact factor: 4.176

Review 7.  Psychologic, vascular, and physiologic aspects of lower limb lengthening in achondroplastics.

Authors:  F Lavini; L Renzi-Brivio; G de Bastiani
Journal:  Clin Orthop Relat Res       Date:  1990-01       Impact factor: 4.176

8.  Lengthening of congenital lower limb deficiencies.

Authors:  C Karger; J T Guille; J R Bowen
Journal:  Clin Orthop Relat Res       Date:  1993-06       Impact factor: 4.176

9.  Limb lengthening in short stature patients.

Authors:  R Aldegheri; C Dall'Oca
Journal:  J Pediatr Orthop B       Date:  2001-07       Impact factor: 1.041

10.  Limb lengthening in children with achondroplasia. Differences based on gender.

Authors:  A Ganel; H Horoszowski
Journal:  Clin Orthop Relat Res       Date:  1996-11       Impact factor: 4.176

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  13 in total

Review 1.  Achondroplasia: Development, pathogenesis, and therapy.

Authors:  David M Ornitz; Laurence Legeai-Mallet
Journal:  Dev Dyn       Date:  2017-03-02       Impact factor: 3.780

Review 2.  Lower extremity growth and deformity.

Authors:  Amanda T Whitaker; Carley Vuillermin
Journal:  Curr Rev Musculoskelet Med       Date:  2016-12

Review 3.  Achondroplasia: a comprehensive clinical review.

Authors:  Richard M Pauli
Journal:  Orphanet J Rare Dis       Date:  2019-01-03       Impact factor: 4.123

4.  Whole-exome sequencing and whole genome re-sequencing for prenatal diagnosis of achondroplasia.

Authors:  Rong Zhao; Yan Ruan; Xin Wang
Journal:  Int J Clin Exp Med       Date:  2015-10-15

Review 5.  Exploring the Ethics of Stature Lengthening as Treatment for Height Dysphoria.

Authors:  Richard C Lee; Mark Aulisio; Raymond W Liu
Journal:  Strategies Trauma Limb Reconstr       Date:  2020 Sep-Dec

6.  Final adult height in long-term growth hormone-treated achondroplasia patients.

Authors:  Daisuke Harada; Noriyuki Namba; Yuki Hanioka; Kaoru Ueyama; Natsuko Sakamoto; Yukako Nakano; Masafumi Izui; Yuiko Nagamatsu; Hiroko Kashiwagi; Miho Yamamuro; Yoshihito Ishiura; Ayako Ogitani; Yoshiki Seino
Journal:  Eur J Pediatr       Date:  2017-05-13       Impact factor: 3.183

Review 7.  Current Care and Investigational Therapies in Achondroplasia.

Authors:  Sheila Unger; Luisa Bonafé; Elvire Gouze
Journal:  Curr Osteoporos Rep       Date:  2017-04       Impact factor: 5.096

8.  Surgical Results of Limb Lengthening at the Femur, Tibia, and Humerus in Patients with Achondroplasia.

Authors:  Kyung Rae Ko; Jong Sup Shim; Chae Hoon Chung; Joo Hwan Kim
Journal:  Clin Orthop Surg       Date:  2019-05-09

9.  Birth prevalence of achondroplasia: A systematic literature review and meta-analysis.

Authors:  Pamela K Foreman; Femke van Kessel; Rosa van Hoorn; Judith van den Bosch; Renée Shediac; Sarah Landis
Journal:  Am J Med Genet A       Date:  2020-08-17       Impact factor: 2.802

Review 10.  Extensive Limb Lengthening for Achondroplasia and Hypochondroplasia.

Authors:  Dror Paley
Journal:  Children (Basel)       Date:  2021-06-24
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