Literature DB >> 25829202

Synthesis and antibacterial evaluation of some teicoplanin pseudoaglycon derivatives containing alkyl- and arylthiosubstituted maleimides.

Magdolna Csávás1, Adrienn Miskovics1, Zsolt Szűcs1, Erzsébet Rőth1, Zsolt L Nagy1, Ilona Bereczki1, Mihály Herczeg1, Gyula Batta2, Éva Nemes-Nikodém3, Eszter Ostorházi3, Ferenc Rozgonyi3, Anikó Borbás1, Pál Herczegh1.   

Abstract

Bis-alkylthio maleimido derivatives have been prepared from teicoplanin pseudoaglycon by reaction of its primary amino group with N-ethoxycarbonyl bis-alkylthiomaleimides. Some of the new derivatives displayed excellent antibacterial activity against resistant bacteria.

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Year:  2015        PMID： 25829202     DOI： 10.1038/ja.2015.33

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  24 in total

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  4 in total

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