Literature DB >> 25829059

UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.

Eduardo R Lazarowski1, T Kendall Harden2.   

Abstract

UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor, a G-protein-coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.
Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics.

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Year:  2015        PMID： 25829059      PMCID： PMC4468635          DOI： 10.1124/mol.115.098756

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


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