Christos V Bourantas1, Lorenz Räber2, Serge Zaugg3, Antonis Sakellarios4, Masanori Taniwaki2, Dik Heg5, Aris Moschovitis2, Maria Radu6, Michail I Papafaklis7, Fanis Kalatzis4, Katerina K Naka7, Dimitrios I Fotiadis4, Lampros K Michalis7, Patrick W Serruys8, Hector M Garcia Garcia8, Stephan Windecker9. 1. Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands; University College of London, London, United Kingdom. 2. Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland. 3. Clinical Trials Unit, Bern University, Bern, Switzerland. 4. Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece. 5. Clinical Trials Unit, Bern University, Bern, Switzerland; Institute of Social and Preventive Medicine, Bern University, Bern, Switzerland. 6. The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 7. Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece. 8. Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands. 9. Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland. Electronic address: stephan.windecker@insel.ch.
Abstract
BACKGROUND: Numerous studies have demonstrated an association between endothelial shear stress (ESS) and neointimal formation after stent implantation. However, the role of ESS on the composition of neointima and underlying plaque remains unclear. METHODS:Patients recruited in the Comfortable AMI-IBIS 4 study implanted withbare metal stents (BMS) or biolimus eluting stents (BES) that had biplane coronary angiography at 13 month follow-up were included in the analysis. The intravascular ultrasound virtual-histology (IVUS-VH) and the angiographic data were used to reconstruct the luminal surface, and the stent in the stented segments. Blood flow simulation was performed in the stent surface, which was assumed to represent the luminal surface at baseline, to assess the association between ESS and neointima thickness. The predominant ESS was estimated in 3-mm segments and was correlated with the amount of neointima, neointimal tissue composition, and with the changes in the underlying plaque burden and composition. RESULTS:Forty three patients (18 implanted with BMS and 25 with BES) were studied. In both stent groups negative correlations were noted between ESS and neointima thickness in BMS (P < 0.001) and BES (P = 0.002). In BMS there was a negative correlation between predominant ESS and the percentage of the neointimal necrotic core component (P = 0.015). In BES group, the limited neointima formation did not allow evaluation of the effect of ESS on its tissue characteristics. ESS did not affect vessel wall remodeling and the plaque burden and composition behind BMS (P > 0.10) and BES (P > 0.45). CONCLUSIONS:ESS determines neointimal formation in both BMS and BES and affects the composition of the neointima in BMS. Conversely, ESS does not impact the plaque behind struts irrespective of stent type throughout 13 months of follow-up.
RCT Entities:
BACKGROUND: Numerous studies have demonstrated an association between endothelial shear stress (ESS) and neointimal formation after stent implantation. However, the role of ESS on the composition of neointima and underlying plaque remains unclear. METHODS:Patients recruited in the Comfortable AMI-IBIS 4 study implanted with bare metal stents (BMS) or biolimus eluting stents (BES) that had biplane coronary angiography at 13 month follow-up were included in the analysis. The intravascular ultrasound virtual-histology (IVUS-VH) and the angiographic data were used to reconstruct the luminal surface, and the stent in the stented segments. Blood flow simulation was performed in the stent surface, which was assumed to represent the luminal surface at baseline, to assess the association between ESS and neointima thickness. The predominant ESS was estimated in 3-mm segments and was correlated with the amount of neointima, neointimal tissue composition, and with the changes in the underlying plaque burden and composition. RESULTS: Forty three patients (18 implanted with BMS and 25 with BES) were studied. In both stent groups negative correlations were noted between ESS and neointima thickness in BMS (P < 0.001) and BES (P = 0.002). In BMS there was a negative correlation between predominant ESS and the percentage of the neointimal necrotic core component (P = 0.015). In BES group, the limited neointima formation did not allow evaluation of the effect of ESS on its tissue characteristics. ESS did not affect vessel wall remodeling and the plaque burden and composition behind BMS (P > 0.10) and BES (P > 0.45). CONCLUSIONS:ESS determines neointimal formation in both BMS and BES and affects the composition of the neointima in BMS. Conversely, ESS does not impact the plaque behind struts irrespective of stent type throughout 13 months of follow-up.
Authors: F Economou; S Katranas; G Giannoglou; K Gemitzis; I Styliadis; G Efthimiadis; H Karvounis; A Ziakas Journal: Herz Date: 2016-10-12 Impact factor: 1.443
Authors: Christos V Bourantas; Farouc A Jaffer; Frank J Gijsen; Gijs van Soest; Sean P Madden; Brian K Courtney; Ali M Fard; Erhan Tenekecioglu; Yaping Zeng; Antonius F W van der Steen; Stanislav Emelianov; James Muller; Peter H Stone; Laura Marcu; Guillermo J Tearney; Patrick W Serruys Journal: Eur Heart J Date: 2017-02-07 Impact factor: 29.983
Authors: Chongying Jin; Ryo Torii; Anantharaman Ramasamy; Vincenzo Tufaro; Callum D Little; Klio Konstantinou; Yi Ying Tan; Nathan A L Yap; Jackie Cooper; Tom Crake; Constantinos O'Mahony; Roby Rakhit; Mohaned Egred; Javed Ahmed; Grigoris Karamasis; Lorenz Räber; Andreas Baumbach; Anthony Mathur; Christos V Bourantas Journal: Front Cardiovasc Med Date: 2022-05-26
Authors: Yakup Kilic; Hannah Safi; Retesh Bajaj; Patrick W Serruys; Pieter Kitslaar; Anantharaman Ramasamy; Vincenzo Tufaro; Yoshinobu Onuma; Anthony Mathur; Ryo Torii; Andreas Baumbach; Christos V Bourantas Journal: Front Cardiovasc Med Date: 2020-03-31