| Literature DB >> 25827522 |
Bandi Yadagiri1, Srikanth Gurrala1, Rajashaker Bantu1, Lingaiah Nagarapu2, Sowjanya Polepalli3, Garimella Srujana3, Nishant Jain3.
Abstract
As an aspect of our ongoing research in search of new anti proliferative agents, a series of novel analogs of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties were synthesized in excellent yields (82-93%). All the newly synthesized compounds were characterized by (1)H NMR, (13)C NMR, ESI/LC-MS, HRMS and evaluated for their in vitro anti proliferative activity against four human cancer cell lines (cervical, breast, pancreatic and alveolar). Among the synthesized compounds, 4b, 6a, 7d and 7l showed potent anti proliferative activity with GI50 values range of 0.079-0.957μM against four human cancer cell lines. However, it was revealed that the compound 7d have shown very close GI50 value 0.079μM as compared with positive control of colchicine against cervical cancer cell line.Entities:
Keywords: 1,2,4-Triazole; 1,3,4-Oxadiazole; 1,3,4-Thiadiazole; Anti-proliferative; Benzosuberone; Cell lines
Mesh：
Substances：
Year: 2015 PMID： 25827522 DOI： 10.1016/j.bmcl.2015.03.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823