Pedro G Cunha1, Jorge Cotter, Pedro Oliveira, Isabel Vila, Pierre Boutouyrie, Stéphane Laurent, Peter M Nilsson, Angelo Scuteri, Nuno Sousa. 1. aDepartment of Internal Medicine, Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Guimarães - Centro Hospitalar do Alto Ave bLife and Health Science Research Institute (ICVS), School of Health Science, University of Minho, Guimarães cICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães dEPI Unit eInstituto de Saúde Pública, Instituto de Ciências Biomédicas Abel Salazar da, Universidade do Porto, Porto, Portugal fDepartment of Pharmacology and INSERM U970, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris, France gDepartment of Clinical Sciences, Lund University, Skane University Hospital, Malmö, Sweden hSan Raffaele Pisana IRCCS, Rome, Italy.
Abstract
BACKGROUND: By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population. METHOD: Pulse wave velocity (PWV) was measured in randomly sampled population dwellers aged 18-96 years from northern Portugal, and used as a marker of early vascular aging (EVA). Of the 3038 individuals enrolled, 2542 completed the evaluation. RESULTS: Mean PWV value for the entire population was 8.4 m/s (men: 8.6 m/s; women: 8.2 m/s; P < 0.02). The individuals were classified with EVA if their PWV was at least 97.5th percentile of z-score for mean PWV values adjusted for age (using normal European reference values as comparators). The overall prevalence of EVA was 12.5%; 26.1% of individuals below 30 years presented this feature and 40.2% of individuals in that same age strata were placed above the 90th percentile of PWV; and 18.7% of the population exhibited PWV values above 10 m/s, with male predominance (17.2% of men aged 40-49 years had PWV > 10 m/s). Logistic regression models indicated gender differences concerning the risk of developing large artery damage, with women having the same odds of PWV above 10 m/s 10 years later than men. CONCLUSION: The population PWV values were higher than expected in a low cardiovascular risk area (Portugal). High prevalence rates of EVA and noteworthy large artery damage in young ages were found.
BACKGROUND: By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population. METHOD: Pulse wave velocity (PWV) was measured in randomly sampled population dwellers aged 18-96 years from northern Portugal, and used as a marker of early vascular aging (EVA). Of the 3038 individuals enrolled, 2542 completed the evaluation. RESULTS: Mean PWV value for the entire population was 8.4 m/s (men: 8.6 m/s; women: 8.2 m/s; P < 0.02). The individuals were classified with EVA if their PWV was at least 97.5th percentile of z-score for mean PWV values adjusted for age (using normal European reference values as comparators). The overall prevalence of EVA was 12.5%; 26.1% of individuals below 30 years presented this feature and 40.2% of individuals in that same age strata were placed above the 90th percentile of PWV; and 18.7% of the population exhibited PWV values above 10 m/s, with male predominance (17.2% of men aged 40-49 years had PWV > 10 m/s). Logistic regression models indicated gender differences concerning the risk of developing large artery damage, with women having the same odds of PWV above 10 m/s 10 years later than men. CONCLUSION: The population PWV values were higher than expected in a low cardiovascular risk area (Portugal). High prevalence rates of EVA and noteworthy large artery damage in young ages were found.
Authors: Shigeki Shibata; Naoki Fujimoto; Jeffrey L Hastings; Graeme Carrick-Ranson; Paul S Bhella; Christopher M Hearon; Benjamin D Levine Journal: J Physiol Date: 2018-05-30 Impact factor: 5.182
Authors: Peter M Nilsson; Stephane Laurent; Pedro G Cunha; Michael H Olsen; Ernst Rietzschel; Oscar H Franco; Ligita Ryliškytė; Irina Strazhesko; Charalambos Vlachopoulos; Chen-Huan Chen; Pierre Boutouyrie; Francesco Cucca; Edward G Lakatta; Angelo Scuteri Journal: J Hypertens Date: 2018-12 Impact factor: 4.844
Authors: Fernando Botto; Sebastian Obregon; Fernando Rubinstein; Angelo Scuteri; Peter M Nilsson; Carol Kotliar Journal: J Hum Hypertens Date: 2018-02-20 Impact factor: 3.012
Authors: S Curcio; V García-Espinosa; M Arana; I Farro; P Chiesa; G Giachetto; Y Zócalo; D Bia Journal: Int J Hypertens Date: 2016-02-18 Impact factor: 2.420