Shengxu Li1, Jinying Zhao2, Guangdi Wang3, Yun Zhu2, Felicia Rabito2, Marie Krousel-Wood4, Wei Chen2, Paul K Whelton2. 1. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States. Electronic address: sli10@tulane.edu. 2. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States. 3. Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, United States. 4. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, United States; Ochsner Health System, New Orleans, LA 70121, United States.
Abstract
BACKGROUND: Humans are extensively exposed to triclosan, an antibacterial and antifungal agent. Triclosan's effects on human health, however, have not been carefully investigated. OBJECTIVE: To examine whether triclosan exposure is associated with obesity traits. METHODS: This study included 2898 children (6-19 years old) and 5066 adults (20 years or older) who participated in the National Health and Nutrition Examination Surveys (NHANES) 2003-2010 and had a detectable level of urinary triclosan. Multiple linear regression models were used to examine the association between urinary triclosan and both body mass index (BMI) and waist circumference. RESULTS: Each standard deviation increase in urinary triclosan was associated with a 0.34 (95% confidence interval, CI: 0.05, 0.64) kg/m² lower level of BMI (P=0.02) and 0.92 (95% CI: 0.09, 1.74)cm smaller waist circumference (P=0.03) in boys, and a 0.62 (95% CI: 0.31, 0.94) kg/m² lower level of BMI (P=0.0002) and 1.32 (95% CI: 0.54, 2.09) cm smaller waist circumference in girls (P=0.001); a 0.42 (95% CI: 0.06, 0.77) kg/m² lower level of BMI (P=0.02) and 1.35 (95% CI: 0.48, 2.22) cm smaller waist circumference (P=0.003) in men, and a 0.71 (95% CI: 0.34, 1.07) kg/m² lower level of BMI (P=0.0002) and 1.68 (95% CI: 0.86, 2.50) cm smaller waist circumference (P=0.0001) in women. In both children and adults, there was a consistent trend for lower levels of BMI and smaller waist circumference with increasing levels of urinary triclosan, from the lowest to the highest quartile of urinary triclosan (P ≤ 0.001 in all cases). CONCLUSION: Triclosan exposure is inversely associated with BMI and waist circumference. The biological mechanisms linking triclosan exposure to obesity await further investigation.
BACKGROUND:Humans are extensively exposed to triclosan, an antibacterial and antifungal agent. Triclosan's effects on human health, however, have not been carefully investigated. OBJECTIVE: To examine whether triclosan exposure is associated with obesity traits. METHODS: This study included 2898 children (6-19 years old) and 5066 adults (20 years or older) who participated in the National Health and Nutrition Examination Surveys (NHANES) 2003-2010 and had a detectable level of urinary triclosan. Multiple linear regression models were used to examine the association between urinary triclosan and both body mass index (BMI) and waist circumference. RESULTS: Each standard deviation increase in urinary triclosan was associated with a 0.34 (95% confidence interval, CI: 0.05, 0.64) kg/m² lower level of BMI (P=0.02) and 0.92 (95% CI: 0.09, 1.74)cm smaller waist circumference (P=0.03) in boys, and a 0.62 (95% CI: 0.31, 0.94) kg/m² lower level of BMI (P=0.0002) and 1.32 (95% CI: 0.54, 2.09) cm smaller waist circumference in girls (P=0.001); a 0.42 (95% CI: 0.06, 0.77) kg/m² lower level of BMI (P=0.02) and 1.35 (95% CI: 0.48, 2.22) cm smaller waist circumference (P=0.003) in men, and a 0.71 (95% CI: 0.34, 1.07) kg/m² lower level of BMI (P=0.0002) and 1.68 (95% CI: 0.86, 2.50) cm smaller waist circumference (P=0.0001) in women. In both children and adults, there was a consistent trend for lower levels of BMI and smaller waist circumference with increasing levels of urinary triclosan, from the lowest to the highest quartile of urinary triclosan (P ≤ 0.001 in all cases). CONCLUSION:Triclosan exposure is inversely associated with BMI and waist circumference. The biological mechanisms linking triclosan exposure to obesity await further investigation.
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