Literature DB >> 19822703

Absorption, pharmacokinetics, and safety of triclosan after dermal administration.

Christian Queckenberg1, Jürgen Meins, Bertil Wachall, Oxana Doroshyenko, Dorota Tomalik-Scharte, Bärbel Bastian, Mona Abdel-Tawab, Uwe Fuhr.   

Abstract

We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 times lower than the relevant no-observed-adverse-effect level. Triclosan can be considered safe for use in hydrophobic creams.

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Year:  2009        PMID： 19822703      PMCID： PMC2798550          DOI： 10.1128/AAC.00615-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Revised guidelines for the control of methicillin-resistant Staphylococcus aureus infection in hospitals. British Society for Antimicrobial Chemotherapy, Hospital Infection Society and the Infection Control Nurses Association.

Authors: 
Journal:  J Hosp Infect       Date:  1998-08       Impact factor: 3.926

2.  Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

Authors:  R McLeod; S P Muench; J B Rafferty; D E Kyle; E J Mui; M J Kirisits; D G Mack; C W Roberts; B U Samuel; R E Lyons; M Dorris; W K Milhous; D W Rice
Journal:  Int J Parasitol       Date:  2001-02       Impact factor: 3.981

3.  Risk assessment of triclosan [Irgasan] in human breast milk.

Authors:  A D Dayan
Journal:  Food Chem Toxicol       Date:  2006-08-30       Impact factor: 6.023

4.  Antiseptic efficacy of a low-dosed topical triclosan/chlorhexidine combination therapy in atopic dermatitis.

Authors:  J Wohlrab; G Jost; D Abeck
Journal:  Skin Pharmacol Physiol       Date:  2006-12-01       Impact factor: 3.479

5.  Pharmacokinetics of triclosan following oral ingestion in humans.

Authors:  Gunilla Sandborgh-Englund; Margaretha Adolfsson-Erici; Göran Odham; Jan Ekstrand
Journal:  J Toxicol Environ Health A       Date:  2006-10

6.  Percutaneous penetration and dermal metabolism of triclosan (2,4, 4'-trichloro-2'-hydroxydiphenyl ether).

Authors:  T Moss; D Howes; F M Williams
Journal:  Food Chem Toxicol       Date:  2000-04       Impact factor: 6.023

7.  Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum.

Authors:  N Surolia; A Surolia
Journal:  Nat Med       Date:  2001-02       Impact factor: 53.440

8.  Buccal absorption of triclosan following topical mouthrinse application.

Authors:  Y J Lin
Journal:  Am J Dent       Date:  2000-08       Impact factor: 1.522

9.  An assessment of triclosan susceptibility in methicillin-resistant and methicillin-sensitive Staphylococcus aureus.

Authors:  A I Bamber; T J Neal
Journal:  J Hosp Infect       Date:  1999-02       Impact factor: 3.926

10.  Urinary concentrations of triclosan in the U.S. population: 2003-2004.

Authors:  Antonia M Calafat; Xiaoyun Ye; Lee-Yang Wong; John A Reidy; Larry L Needham
Journal:  Environ Health Perspect       Date:  2008-03       Impact factor: 9.031
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  31 in total

1.  Urinary triclosan concentrations are inversely associated with body mass index and waist circumference in the US general population: Experience in NHANES 2003-2010.

Authors:  Shengxu Li; Jinying Zhao; Guangdi Wang; Yun Zhu; Felicia Rabito; Marie Krousel-Wood; Wei Chen; Paul K Whelton
Journal:  Int J Hyg Environ Health       Date:  2015-03-14       Impact factor: 5.840

2.  Exposure to triclosan among pregnant women in northern China: urinary concentrations, sociodemographic predictors, and seasonal variability.

Authors:  Chenye Jin; Qian Yao; Yijun Zhou; Rong Shi; Yu Gao; Caifeng Wang; Ying Tian
Journal:  Environ Sci Pollut Res Int       Date:  2019-12-16       Impact factor: 4.223

Review 3.  Triclosan exposure, transformation, and human health effects.

Authors:  Lisa M Weatherly; Julie A Gosse
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2017       Impact factor: 6.393

4.  Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.

Authors:  Gennady Cherednichenko; Rui Zhang; Roger A Bannister; Valeriy Timofeyev; Ning Li; Erika B Fritsch; Wei Feng; Genaro C Barrientos; Nils H Schebb; Bruce D Hammock; Kurt G Beam; Nipavan Chiamvimonvat; Isaac N Pessah
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-13       Impact factor: 11.205

5.  Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughput in vitro Data, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling.

Authors:  Jeremy A Leonard; Yu-Mei Tan; Mary Gilbert; Kristin Isaacs; Hisham El-Masri
Journal:  Toxicol Sci       Date:  2016-02-10       Impact factor: 4.849

6.  Triclosan and triclocarban exposure and thyroid function during pregnancy-A randomized intervention.

Authors:  Catherine Ley; Lauren Pischel; Julie Parsonnet
Journal:  Reprod Toxicol       Date:  2017-09-20       Impact factor: 3.143

7.  Health care worker exposures to the antibacterial agent triclosan.

Authors:  Julia K MacIsaac; Roy R Gerona; Paul D Blanc; Latifat Apatira; Matthew W Friesen; Michael Coppolino; Sarah Janssen
Journal:  J Occup Environ Med       Date:  2014-08       Impact factor: 2.162

8.  Triclosan disrupts immune cell function by depressing Ca2+ influx following acidification of the cytoplasm.

Authors:  Suraj Sangroula; Alan Y Baez Vasquez; Prakash Raut; Bright Obeng; Juyoung K Shim; Grace D Bagley; Bailey E West; John E Burnell; Marissa S Kinney; Christian M Potts; Sasha R Weller; Joshua B Kelley; Samuel T Hess; Julie A Gosse
Journal:  Toxicol Appl Pharmacol       Date:  2020-08-21       Impact factor: 4.219

Review 9.  Triclosan: A Widespread Environmental Toxicant with Many Biological Effects.

Authors:  Mei-Fei Yueh; Robert H Tukey
Journal:  Annu Rev Pharmacol Toxicol       Date:  2016       Impact factor: 13.820

10.  Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus.

Authors:  Hui Wang; Yang Lu; Li Liu; Sung Won Kim; Jacob M Hooker; Joanna S Fowler; Peter J Tonge
Journal:  Eur J Med Chem       Date:  2014-09-06       Impact factor: 6.514
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