INTRODUCTION: Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown. PURPOSE: To explore the effects of central and peripheral irisin on cardiovascular functions. METHODS: Irisin was either administrated into 3rd ventricle of rats or intravenously, and its effects on blood pressure and cardiac contractibility measured. RESULTS: Administration of recombinant human irisin into the 3rd brain ventricle of rats activated neurons in the paraventricular nuclei of the hypothalamus. Central administration of irisin increased blood pressure and cardiac contractibility. Exogenous irisin reversed atenolol-induced inhibition of cardiac contractibility. In contrast, peripheral administration of irisin reduced blood pressure in both control and spontaneously hypertensive rats. Irisin dilated mesenteric artery rings through ATP-sensitive potassium channels. CONCLUSION: Our studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities.
INTRODUCTION:Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown. PURPOSE: To explore the effects of central and peripheral irisin on cardiovascular functions. METHODS:Irisin was either administrated into 3rd ventricle of rats or intravenously, and its effects on blood pressure and cardiac contractibility measured. RESULTS: Administration of recombinant humanirisin into the 3rd brain ventricle of rats activated neurons in the paraventricular nuclei of the hypothalamus. Central administration of irisin increased blood pressure and cardiac contractibility. Exogenous irisin reversed atenolol-induced inhibition of cardiac contractibility. In contrast, peripheral administration of irisin reduced blood pressure in both control and spontaneously hypertensiverats. Irisin dilated mesenteric artery rings through ATP-sensitive potassium channels. CONCLUSION: Our studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities.
Authors: G Sesti; F Andreozzi; T V Fiorentino; G C Mannino; A Sciacqua; M A Marini; F Perticone Journal: Acta Diabetol Date: 2014-03-12 Impact factor: 4.280
Authors: Timea Kurdiova; Miroslav Balaz; Marek Vician; Denisa Maderova; Miroslav Vlcek; Ladislav Valkovic; Miroslav Srbecky; Richard Imrich; Olga Kyselovicova; Vitazoslav Belan; Ivan Jelok; Christian Wolfrum; Iwar Klimes; Martin Krssak; Erika Zemkova; Daniela Gasperikova; Jozef Ukropec; Barbara Ukropcova Journal: J Physiol Date: 2013-12-02 Impact factor: 5.182
Authors: Pontus Boström; Jun Wu; Mark P Jedrychowski; Anisha Korde; Li Ye; James C Lo; Kyle A Rasbach; Elisabeth Almer Boström; Jang Hyun Choi; Jonathan Z Long; Shingo Kajimura; Maria Cristina Zingaretti; Birgitte F Vind; Hua Tu; Saverio Cinti; Kurt Højlund; Steven P Gygi; Bruce M Spiegelman Journal: Nature Date: 2012-01-11 Impact factor: 49.962
Authors: Julia Brenmoehl; Elke Albrecht; Katrin Komolka; Lisa Schering; Martina Langhammer; Andreas Hoeflich; Steffen Maak Journal: Int J Biol Sci Date: 2014-03-11 Impact factor: 6.580
Authors: Pedro L Valenzuela; Pedro Carrera-Bastos; Beatriz G Gálvez; Gema Ruiz-Hurtado; José M Ordovas; Luis M Ruilope; Alejandro Lucia Journal: Nat Rev Cardiol Date: 2020-10-09 Impact factor: 32.419
Authors: A B Fagundo; S Jiménez-Murcia; C Giner-Bartolomé; Z Agüera; S Sauchelli; M Pardo; A B Crujeiras; R Granero; R Baños; C Botella; R de la Torre; J M Fernández-Real; J C Fernández-García; G Frühbeck; A Rodríguez; N Mallorquí-Bagué; S Tárrega; F J Tinahones; R Rodriguez; F Ortega; J M Menchón; F F Casanueva; F Fernández-Aranda Journal: Sci Rep Date: 2016-08-01 Impact factor: 4.379