A L Mark1, K Rahmouni, M Correia, W G Haynes. 1. Specialized Center of Research in Hypertension Genetics, the Department of Internal Medicine, Lucille A Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA 52242-1101, USA.
Abstract
AIM: This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop. RESULTS: Leptin increases sympathetic nerve activity to brown adipose tissue, kidney and other tissues. This action has implications for regulation of arterial pressure. In turn, there is evidence that sympathoadrenal stimulation inhibits leptin mRNA expression and secretion from white adipose tissue through beta adrenergic mechanisms. CONCLUSION: This sympathetic modulation of leptin expression has potential implications for regulation of body fat.
AIM: This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop. RESULTS: Leptin increases sympathetic nerve activity to brown adipose tissue, kidney and other tissues. This action has implications for regulation of arterial pressure. In turn, there is evidence that sympathoadrenal stimulation inhibits leptin mRNA expression and secretion from white adipose tissue through beta adrenergic mechanisms. CONCLUSION: This sympathetic modulation of leptin expression has potential implications for regulation of body fat.
Authors: Tahzeeb Fatima; Sara Altaf; Amanda Phipps-Green; Ruth Topless; Tanya J Flynn; Lisa K Stamp; Nicola Dalbeth; Tony R Merriman Journal: Rheumatol Int Date: 2015-09-26 Impact factor: 2.631
Authors: A Janet Tomiyama; Imke Schamarek; Robert H Lustig; Clemens Kirschbaum; Eli Puterman; Peter J Havel; Elissa S Epel Journal: Physiol Behav Date: 2012-05-02