Literature DB >> 25819274

Myosin-X and disease.

David S Courson1, Richard E Cheney2.   

Abstract

Myosin-X (Myo10) is a motor protein best known for its role in filopodia formation. New research implicates Myo10 in a number of disease states including cancer metastasis and pathogen infection. This review focuses on these developments with emphasis on the emerging roles of Myo10 in formation of cancer cell protrusions and metastasis. A number of aggressive cancers show high levels of Myo10 expression and knockdown of Myo10 has been shown to dramatically limit cancer cell motility in 2D and 3D systems. Myo10 knockdown also limits spread of intracellular pathogens marburgvirus and Shigella flexneri. Consideration is given to how these properties might arise and potential paths of future research.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cancer; Filopodia; Infectious disease; Metastasis; Myo10; Myosin-X

Mesh：

Substances：

Year:  2015        PMID： 25819274      PMCID： PMC4433855          DOI： 10.1016/j.yexcr.2015.03.014

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  55 in total

1.  Budding of Marburgvirus is associated with filopodia.

Authors:  Larissa Kolesnikova; Aparna B Bohil; Richard E Cheney; Stephan Becker
Journal:  Cell Microbiol       Date:  2006-11-28       Impact factor: 3.715

2.  Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner.

Authors:  Fumiko Toyoshima; Eisuke Nishida
Journal:  EMBO J       Date:  2007-02-22       Impact factor: 11.598

3.  Prognostic significance of fascin overexpression in human esophageal squamous cell carcinoma.

Authors:  Yosuke Hashimoto; Tetsuo Ito; Harutaka Inoue; Tomoyuki Okumura; Eiji Tanaka; Shigeru Tsunoda; Motoshige Higashiyama; Go Watanabe; Masayuki Imamura; Yutaka Shimada
Journal:  Clin Cancer Res       Date:  2005-04-01       Impact factor: 12.531

4.  Myosin-X is a molecular motor that functions in filopodia formation.

Authors:  Aparna B Bohil; Brian W Robertson; Richard E Cheney
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-07       Impact factor: 11.205

5.  The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course.

Authors:  Brian J Yoder; Elisa Tso; Marek Skacel; Jim Pettay; Shannon Tarr; Thomas Budd; Raymond R Tubbs; Josephine C Adams; David G Hicks
Journal:  Clin Cancer Res       Date:  2005-01-01       Impact factor: 12.531

6.  Myosin X regulates netrin receptors and functions in axonal path-finding.

Authors:  Xiao-Juan Zhu; Cheng-Zhong Wang; Peng-Gao Dai; Yi Xie; Ning-Ning Song; Yu Liu; Quan-Sheng Du; Lin Mei; Yu-Qiang Ding; Wen-Cheng Xiong
Journal:  Nat Cell Biol       Date:  2007-01-21       Impact factor: 28.824

7.  Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer.

Authors:  Danijela Vignjevic; Marie Schoumacher; Nancy Gavert; Klaus-Peter Janssen; Gloria Jih; Marick Laé; Daniel Louvard; Avri Ben-Ze'ev; Sylvie Robine
Journal:  Cancer Res       Date:  2007-07-15       Impact factor: 12.701

8.  The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head.

Authors:  Peter J Knight; Kavitha Thirumurugan; Yuhui Xu; Fei Wang; Arnout P Kalverda; Walter F Stafford; James R Sellers; Michelle Peckham
Journal:  J Biol Chem       Date:  2005-07-18       Impact factor: 5.157

9.  Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas.

Authors:  Yosuke Hashimoto; Marek Skacel; Ian C Lavery; Abir L Mukherjee; Graham Casey; Josephine C Adams
Journal:  BMC Cancer       Date:  2006-10-09       Impact factor: 4.430

10.  The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.

Authors:  Hiroshi Tokuo; Katsuhide Mabuchi; Mitsuo Ikebe
Journal:  J Cell Biol       Date:  2007-10-22       Impact factor: 10.539
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  13 in total

1.  Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection.

Authors:  Kevin C Vavra; Youlin Xia; Ronald S Rock
Journal:  Biophys J       Date:  2016-06-07       Impact factor: 4.033

2.  Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions.

Authors:  Manmeet H Raval; Omar A Quintero; Meredith L Weck; William C Unrath; James W Gallagher; Runjia Cui; Bechara Kachar; Matthew J Tyska; Christopher M Yengo
Journal:  J Biol Chem       Date:  2016-08-31       Impact factor: 5.157

3.  The Antiparallel Dimerization of Myosin X Imparts Bundle Selectivity for Processive Motility.

Authors:  Matthew A Caporizzo; Claire E Fishman; Osamu Sato; Ryan M Jamiolkowski; Mitsuo Ikebe; Yale E Goldman
Journal:  Biophys J       Date:  2018-03-27       Impact factor: 4.033

4.  Measured maternal prepregnancy anthropometry and newborn DNA methylation.

Authors:  Edwina H Yeung; Weihua Guan; Sunni L Mumford; Robert M Silver; Cuilin Zhang; Michael Y Tsai; Enrique F Schisterman
Journal:  Epigenomics       Date:  2019-01-08       Impact factor: 4.778

5.  Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.

Authors:  Jianchao Li; Yunyun He; Meredith L Weck; Qing Lu; Matthew J Tyska; Mingjie Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-24       Impact factor: 11.205

6.  The myosin regulatory light chain Myl5 localizes to mitotic spindle poles and is required for proper cell division.

Authors:  Ivan Ramirez; Ankur A Gholkar; Erick F Velasquez; Xiao Guo; Bobby Tofig; Robert Damoiseaux; Jorge Z Torres
Journal:  Cytoskeleton (Hoboken)       Date:  2021-03-08

7.  The myosin X motor is optimized for movement on actin bundles.

Authors:  Virginie Ropars; Zhaohui Yang; Tatiana Isabet; Florian Blanc; Kaifeng Zhou; Tianming Lin; Xiaoyan Liu; Pascale Hissier; Frédéric Samazan; Béatrice Amigues; Eric D Yang; Hyokeun Park; Olena Pylypenko; Marco Cecchini; Charles V Sindelar; H Lee Sweeney; Anne Houdusse
Journal:  Nat Commun       Date:  2016-09-01       Impact factor: 14.919

8.  A composite network of conserved and tissue specific gene interactions reveals possible genetic interactions in glioma.

Authors:  André Voigt; Katja Nowick; Eivind Almaas
Journal:  PLoS Comput Biol       Date:  2017-09-28       Impact factor: 4.475

9.  Myosin-X knockout is semi-lethal and demonstrates that myosin-X functions in neural tube closure, pigmentation, hyaloid vasculature regression, and filopodia formation.

Authors:  Ernest G Heimsath; Yang-In Yim; Mirna Mustapha; John A Hammer; Richard E Cheney
Journal:  Sci Rep       Date:  2017-12-11       Impact factor: 4.379

10.  Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.

Authors:  Jian-Hui He; Jian-Guo Chen; Bin Zhang; Jing Chen; Ke-Li You; Jie-Mei Hu; Jia-Wen Xu; Le Chen
Journal:  Technol Cancer Res Treat       Date:  2020 Jan-Dec
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