Edwina H Yeung1, Weihua Guan2, Sunni L Mumford1, Robert M Silver3,4, Cuilin Zhang1, Michael Y Tsai5, Enrique F Schisterman1. 1. Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, 6710B Rockledge Drive 7004, Bethesda, MD 20817, USA. 2. Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, MMC 303, 420 Delaware St SE, Minneapolis, MN 55455, USA. 3. Department of Obstetrics & Gynecology, University of Utah, 50 North Medical Drive, Room 2B200, Salt Lake City, UT 84103, USA. 4. Intermountain Healthcare, Salt Lake City, 50 North Medical Drive, Salt Lake City, UT 84132, USA. 5. Department of Laboratory Medicine & Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Abstract
AIM: We examined maternal prepregnancy anthropometry and cord blood DNA methylation. METHODS: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons. RESULTS: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10-8). A suggestive association (p < 10-6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. CONCLUSION: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.
AIM: We examined maternal prepregnancy anthropometry and cord blood DNA methylation. METHODS: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons. RESULTS: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10-8). A suggestive association (p < 10-6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. CONCLUSION: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.
Entities:
Keywords:
DNA methylation; maternal obesity; newborn; pregnancy
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