Literature DB >> 25818864

Codification of bidentate pMHC interaction with TCR and its co-receptor.

Ellis L Reinherz1, Jia-huai Wang2.   

Abstract

A 1983 Immunology Today rostrum hypothesized that each T cell has two recognition units: a T cell receptor (<span class="Gene">TCR) complex, which binds antigen associated with a polymorphic region of a MHC molecule (pMHC), and a CD4 or CD8 molecule that binds to a conserved region of that same MHC gene product (class II or I, respectively). Structural biology has since precisely revealed those bidentate pMHC interactions. TCRαβ ligates the membrane-distal antigen-binding MHC platform, whereas CD8 clamps a membrane-proximal MHCI α3 domain loop and CD4 docks to a hydrophobic crevice between MHCII α2 and β2 domains. Here, we review how MHC class-restricted binding impacts signaling and lineage commitment, discussing TCR force-driven conformational transitions that may optimally expose the co-receptor docking site on MHC.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  TCR; antigen recognition; co-receptor; mechanobiology

Mesh：

Substances：

Year:  2015        PMID： 25818864      PMCID： PMC4420642          DOI： 10.1016/j.it.2015.03.004

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  66 in total

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Journal:  Immunity       Date:  2000-04       Impact factor: 31.745

Review 2.  Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands.

Authors:  George F Gao; Zihe Rao; John I Bell
Journal:  Trends Immunol       Date:  2002-08       Impact factor: 16.687

3.  Separation of functional subsets of human T cells by a monoclonal antibody.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

4.  A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  J Immunol       Date:  1980-03       Impact factor: 5.422

5.  Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.

Authors:  Anne Marie Moody; Simon J North; Bruce Reinhold; Steven J Van Dyken; Mark E Rogers; Maria Panico; Anne Dell; Howard R Morris; Jamey D Marth; Ellis L Reinherz
Journal:  J Biol Chem       Date:  2002-11-28       Impact factor: 5.157

6.  Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers.

Authors:  P Kern; R E Hussey; R Spoerl; E L Reinherz; H C Chang
Journal:  J Biol Chem       Date:  1999-09-17       Impact factor: 5.157

7.  Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes.

Authors:  S C Meuer; D A Cooper; J C Hodgdon; R E Hussey; K A Fitzgerald; S F Schlossman; E L Reinherz
Journal:  Science       Date:  1983-12-16       Impact factor: 47.728

Review 8.  T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.

Authors:  Jennifer D Stone; Adam S Chervin; David M Kranz
Journal:  Immunology       Date:  2009-02       Impact factor: 7.397

9.  Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.

Authors:  Konstantina Nika; Cristiana Soldani; Mogjiborahman Salek; Wolfgang Paster; Adrian Gray; Ruth Etzensperger; Lars Fugger; Paolo Polzella; Vincenzo Cerundolo; Omer Dushek; Thomas Höfer; Antonella Viola; Oreste Acuto
Journal:  Immunity       Date:  2010-06-11       Impact factor: 31.745

Review 10.  Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset Commitment.

Authors:  Xiao-Long Li; Mai-Kun Teng; Ellis L Reinherz; Jia-Huai Wang
Journal:  Front Immunol       Date:  2013-11-22       Impact factor: 7.561
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Review 5.  αβ T Cell Receptor Mechanosensing Forces out Serial Engagement.

Authors:  Yinnian Feng; Ellis L Reinherz; Matthew J Lang
Journal:  Trends Immunol       Date:  2018-07-04       Impact factor: 16.687

Review 6.  RhoA as a Key Regulator of Innate and Adaptive Immunity.

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Journal:  Cells       Date:  2019-07-17       Impact factor: 6.600

7.  Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes.

Authors:  Lue Ping Zhao; George K Papadopoulos; William W Kwok; Bryan Xu; Matthew Kong; Antonis K Moustakas; George P Bondinas; Annelie Carlsson; Helena Elding-Larsson; Johnny Ludvigsson; Claude Marcus; Martina Persson; Ulf Samuelsson; Ruihan Wang; Chul-Woo Pyo; Wyatt C Nelson; Daniel E Geraghty; Åke Lernmark
Journal:  Diabetes       Date:  2019-05-24       Impact factor: 9.461
  7 in total

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