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Literature DB >> 10795736

Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment.

Abstract

We undertook a kinetic analysis of the generation of mature T cells in TCR and coreceptor transgenic mice using BrdU labeling. We observed that the selection efficiency of mature CD4-CD8+ and CD4+CD8- thymocytes could be as high as 40% and 90% of CD4+CD8+ precursors, respectively. The surprisingly high efficiency of selection favors an instructional model of lineage commitment and is incompatible with a stochastic model in which the efficiency of selection would be no greater than 100% in both lineages combined.

Entities: Gene Species

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Year: 2000 PMID： 10795736 DOI： 10.1016/s1074-7613(00)80190-9

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

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Cited

12 in total

1. Detailed analysis of gene expression during development of T cell lineages in the thymus.

Authors: Nami McCarty; Mari L Shinohara; Linrong Lu; Harvey Cantor
Journal: Proc Natl Acad Sci U S A Date: 2004-06-09 Impact factor: 11.205

2. Familial CD8 deficiency due to a mutation in the CD8 alpha gene.

Authors: O de la Calle-Martin; M Hernandez; J Ordi; N Casamitjana; J I Arostegui; I Caragol; M Ferrando; M Labrador; J L Rodriguez-Sanchez; T Espanol
Journal: J Clin Invest Date: 2001-07 Impact factor: 14.808

Review 3. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

Authors: Alfred Singer; Stanley Adoro; Jung-Hyun Park
Journal: Nat Rev Immunol Date: 2008-10 Impact factor: 53.106

Review 4. Codification of bidentate pMHC interaction with TCR and its co-receptor.

Authors: Ellis L Reinherz; Jia-huai Wang
Journal: Trends Immunol Date: 2015-03-26 Impact factor: 16.687

5. Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides.

Authors: Jason T George; David A Kessler; Herbert Levine
Journal: Proc Natl Acad Sci U S A Date: 2017-09-05 Impact factor: 11.205

6. Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

Authors: Sophia D Sarafova; Francois Van Laethem; Stanley Adoro; Terry Guinter; Susan O Sharrow; Lionel Feigenbaum; Alfred Singer
Journal: Immunity Date: 2009-09-10 Impact factor: 31.745

Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment.

1. Detailed analysis of gene expression during development of T cell lineages in the thymus.

2. Familial CD8 deficiency due to a mutation in the CD8 alpha gene.

Review 3. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.

Review 4. Codification of bidentate pMHC interaction with TCR and its co-receptor.

5. Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides.

6. Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.

7. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.

8. Dynamic repositioning of CD4 and CD8 genes during T cell development.

9. Presenilins regulate alphabeta T cell development by modulating TCR signaling.

Review 10. Theories and quantification of thymic selection.