Literature DB >> 25817192

The curious incident of the translational dog that didn't bark.

Stefano Bertuzzi1, Don W Cleveland2.   

Abstract

There is a general assumption that it is now time for more translational research and less basic research. Science policy leaders have sent mixed signals and the community has responded by submitting more grant applications focused on translational or applied research. Nothing could be more treacherous, because to develop innovative therapies we must more fully understand the complexities of biology, a goal requiring more, not less, basic science.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  NIH; basic science; funding; precision medicine; science policy

Mesh:

Year:  2015        PMID: 25817192      PMCID: PMC4508195          DOI: 10.1016/j.tcb.2015.02.003

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN: 0962-8924            Impact factor:   20.808


  4 in total

Review 1.  Biology of childhood acute lymphoblastic leukemia.

Authors:  Deepa Bhojwani; Jun J Yang; Ching-Hon Pui
Journal:  Pediatr Clin North Am       Date:  2015-02       Impact factor: 3.278

2.  A new initiative on precision medicine.

Authors:  Francis S Collins; Harold Varmus
Journal:  N Engl J Med       Date:  2015-01-30       Impact factor: 91.245

3.  Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.

Authors:  B Beutler; I W Milsark; A C Cerami
Journal:  Science       Date:  1985-08-30       Impact factor: 47.728

4.  Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.

Authors:  J Vilcek; V J Palombella; D Henriksen-DeStefano; C Swenson; R Feinman; M Hirai; M Tsujimoto
Journal:  J Exp Med       Date:  1986-03-01       Impact factor: 14.307

  4 in total
  2 in total

1.  Pragmatic medicine in solid cancer: a translational alternative to precision medicine.

Authors:  Jan Brábek; Daniel Rosel; Michael Fernandes
Journal:  Onco Targets Ther       Date:  2016-04-05       Impact factor: 4.147

Review 2.  Animal models in psychiatric research: The RDoC system as a new framework for endophenotype-oriented translational neuroscience.

Authors:  Elmira Anderzhanova; Thomas Kirmeier; Carsten T Wotjak
Journal:  Neurobiol Stress       Date:  2017-03-25
  2 in total

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