Literature DB >> 25435111

Biology of childhood acute lymphoblastic leukemia.

Deepa Bhojwani1, Jun J Yang2, Ching-Hon Pui3.   

Abstract

Giant strides have been made in the management of childhood acute lymphoblastic leukemia (ALL) over previous decades. Extensive collaborative efforts internationally have played a vital role in the remarkable progress made in not only improving therapeutic outcomes but also deciphering the complex biology of childhood ALL. This review summarizes various insights gained from biological studies of childhood ALL, with a focus on recent studies, and also discusses genomic lesions and epigenetic regulatory mechanisms associated with leukemic transformation. The importance of studying the biology of the host so as to understand additional heterogeneity in treatment response and toxicities is highlighted.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Childhood acute lymphoblastic leukemia; Chromosomal alterations; Genomics; Host germline polymorphisms

Mesh：

Year:  2015        PMID： 25435111      PMCID： PMC4250840          DOI： 10.1016/j.pcl.2014.09.004

Source DB:  PubMed          Journal:  Pediatr Clin North Am        ISSN： 0031-3955            Impact factor:   3.278


  69 in total

1.  Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies.

Authors:  Laura E Hogan; Julia A Meyer; Jun Yang; Jinhua Wang; Nicholas Wong; Wenjian Yang; Gregory Condos; Stephen P Hunger; Elizabeth Raetz; Richard Saffery; Mary V Relling; Deepa Bhojwani; Debra J Morrison; William L Carroll
Journal:  Blood       Date:  2011-09-14       Impact factor: 22.113

2.  Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia.

Authors:  C Virely; S Moulin; C Cobaleda; C Lasgi; A Alberdi; J Soulier; F Sigaux; S Chan; P Kastner; J Ghysdael
Journal:  Leukemia       Date:  2010-04-15       Impact factor: 11.528

3.  Risks of leukaemia and solid tumours in individuals with Down's syndrome.

Authors:  H Hasle; I H Clemmensen; M Mikkelsen
Journal:  Lancet       Date:  2000-01-15       Impact factor: 79.321

4.  Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG).

Authors:  Kirk R Schultz; D Jeanette Pullen; Harland N Sather; Jonathan J Shuster; Meenakshi Devidas; Michael J Borowitz; Andrew J Carroll; Nyla A Heerema; Jeffrey E Rubnitz; Mignon L Loh; Elizabeth A Raetz; Naomi J Winick; Stephen P Hunger; William L Carroll; Paul S Gaynon; Bruce M Camitta
Journal:  Blood       Date:  2006-09-26       Impact factor: 22.113

5.  Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.

Authors:  Elaine Coustan-Smith; Charles G Mullighan; Mihaela Onciu; Frederick G Behm; Susana C Raimondi; Deqing Pei; Cheng Cheng; Xiaoping Su; Jeffrey E Rubnitz; Giuseppe Basso; Andrea Biondi; Ching-Hon Pui; James R Downing; Dario Campana
Journal:  Lancet Oncol       Date:  2009-01-13       Impact factor: 41.316

6.  Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.

Authors:  Charles G Mullighan; J Racquel Collins-Underwood; Letha A A Phillips; Michael G Loudin; Wei Liu; Jinghui Zhang; Jing Ma; Elaine Coustan-Smith; Richard C Harvey; Cheryl L Willman; Fady M Mikhail; Julia Meyer; Andrew J Carroll; Richard T Williams; Jinjun Cheng; Nyla A Heerema; Giuseppe Basso; Andrea Pession; Ching-Hon Pui; Susana C Raimondi; Stephen P Hunger; James R Downing; William L Carroll; Karen R Rabin
Journal:  Nat Genet       Date:  2009-10-18       Impact factor: 38.330

7.  Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia.

Authors:  Maria E Figueroa; Shann-Ching Chen; Anna K Andersson; Letha A Phillips; Yushan Li; Jason Sotzen; Mondira Kundu; James R Downing; Ari Melnick; Charles G Mullighan
Journal:  J Clin Invest       Date:  2013-06-10       Impact factor: 14.808

8.  Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.

Authors:  E Ellinghaus; M Stanulla; G Richter; D Ellinghaus; G te Kronnie; G Cario; G Cazzaniga; M Horstmann; R Panzer Grümayer; H Cavé; J Trka; O Cinek; A Teigler-Schlegel; A ElSharawy; R Häsler; A Nebel; B Meissner; T Bartram; F Lescai; C Franceschi; M Giordan; P Nürnberg; B Heinzow; M Zimmermann; S Schreiber; M Schrappe; A Franke
Journal:  Leukemia       Date:  2011-11-11       Impact factor: 11.528

9.  Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003.

Authors:  Katharine Patrick; Rachel Wade; Nick Goulden; Chris Mitchell; Anthony V Moorman; Clare Rowntree; Sarah Jenkinson; Rachael Hough; Ajay Vora
Journal:  Br J Haematol       Date:  2014-04-08       Impact factor: 6.998

10.  Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.

Authors:  Pedro J Real; Valeria Tosello; Teresa Palomero; Mireia Castillo; Eva Hernando; Elisa de Stanchina; Maria Luisa Sulis; Kelly Barnes; Catherine Sawai; Irene Homminga; Jules Meijerink; Iannis Aifantis; Giuseppe Basso; Carlos Cordon-Cardo; Walden Ai; Adolfo Ferrando
Journal:  Nat Med       Date:  2008-12-21       Impact factor: 53.440
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  52 in total

1.  The curious incident of the translational dog that didn't bark.

Authors:  Stefano Bertuzzi; Don W Cleveland
Journal:  Trends Cell Biol       Date:  2015-04       Impact factor: 20.808

2.  Survival among children diagnosed with acute lymphoblastic leukemia in the United States, by race and age, 2001 to 2009: Findings from the CONCORD-2 study.

Authors:  Eric W Tai; Kevin C Ward; Audrey Bonaventure; David A Siegel; Michel P Coleman
Journal:  Cancer       Date:  2017-12-15       Impact factor: 6.860

Review 3.  Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia.

Authors:  Alejandra Sanjuan-Pla; Clara Bueno; Cristina Prieto; Pamela Acha; Ronald W Stam; Rolf Marschalek; Pablo Menéndez
Journal:  Blood       Date:  2015-10-13       Impact factor: 22.113

4.  Changes in cognition and dendritic complexity following intrathecal methotrexate and cytarabine treatment in a juvenile murine model.

Authors:  Tyler C Alexander; Christy M Simecka; Frederico Kiffer; Thomas Groves; Julie Anderson; Hannah Carr; Jing Wang; Gwendolyn Carter; Antiño R Allen
Journal:  Behav Brain Res       Date:  2017-12-08       Impact factor: 3.332

5.  In vitro analysis of microRNA-26a in chronic lymphocytic leukemia cells.

Authors:  Jing Li; Chang-Kui Sun
Journal:  Int J Mol Med       Date:  2018-10-10       Impact factor: 4.101

Review 6.  New targeted therapies for relapsed pediatric acute lymphoblastic leukemia.

Authors:  Joanna Pierro; Laura E Hogan; Teena Bhatla; William L Carroll
Journal:  Expert Rev Anticancer Ther       Date:  2017-07-05       Impact factor: 4.512

Review 7.  Integrating evolutionary dynamics into cancer therapy.

Authors:  Robert A Gatenby; Joel S Brown
Journal:  Nat Rev Clin Oncol       Date:  2020-07-22       Impact factor: 66.675

8.  Prognostic significance of the tumor suppressor protein p53 gene in childhood acute lymphoblastic leukemia.

Authors:  Wenwen Weng; Ping Zhang; Jinfei Ruan; Yao Zhang; Diandian Ba; Yongmin Tang
Journal:  Oncol Lett       Date:  2019-11-07       Impact factor: 2.967

Review 9.  The New Therapeutic Strategies in Pediatric T-Cell Acute Lymphoblastic Leukemia.

Authors:  Marta Weronika Lato; Anna Przysucha; Sylwia Grosman; Joanna Zawitkowska; Monika Lejman
Journal:  Int J Mol Sci       Date:  2021-04-26       Impact factor: 5.923

Review 10.  Epigenetic Effects of Benzene in Hematologic Neoplasms: The Altered Gene Expression.

Authors:  Giovanna Spatari; Alessandro Allegra; Mariella Carrieri; Giovanni Pioggia; Sebastiano Gangemi
Journal:  Cancers (Basel)       Date:  2021-05-14       Impact factor: 6.639
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