Literature DB >> 25814783

Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.

Akio Nakashima1, Fuyuhiko Tamanoi1.   

Abstract

The TSC/Rheb/TORC1/S6K/S6 signaling pathway plays critical roles in regulating protein synthesis and growth in eukaryotes. Our recent work using fission yeast Schizosaccharomyces pombe revealed that this signaling pathway is conserved from humans to fission yeast. In addition to target of rapamycin (TOR) homologsand tuberous sclerosis complex (TSC) homologs, fission yeast but not budding yeast, has a functional homolog of Rheb, a small G-protein acting as an activator of TOR complex 1 (TORC1). Several lines of genetic evidence suggest that the Tsc1-Tsc2 complex and Rheb act as upstream players of TORC1 in fission yeast. We have recently demonstrated that TORC1, but not TORC2, regulates phosphorylation of ribosomal protein S6 in response to nutrient availability. Candidate S6 kinase (S6K) protein has been identified. In addition, we find that rapamycin prevents a subset of TORC1 activity to regulate S6 phosphorylation in fission yeast.

Entities:  

Year:  2010        PMID： 25814783      PMCID： PMC4371861          DOI： 10.1016/S1874-6047(10)28008-3

Source DB:  PubMed          Journal:  Enzymes        ISSN： 1874-6047


  76 in total

1.  Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

Authors:  Marjon van Slegtenhorst; Aladdin Mustafa; Elizabeth Petri Henske
Journal:  Hum Mol Genet       Date:  2005-08-22       Impact factor: 6.150

2.  Fission yeast Tor2 promotes cell growth and represses cell differentiation.

Authors:  Beatriz Alvarez; Sergio Moreno
Journal:  J Cell Sci       Date:  2006-10-17       Impact factor: 5.285

3.  TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

Authors:  M C Lorenz; J Heitman
Journal:  J Biol Chem       Date:  1995-11-17       Impact factor: 5.157

4.  Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells.

Authors:  Jun Urano; Tatsuhiro Sato; Tomohiko Matsuo; Yoko Otsubo; Masayuki Yamamoto; Fuyuhiko Tamanoi
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-20       Impact factor: 11.205

5.  Identification and characterization of the tuberous sclerosis gene on chromosome 16.

Authors: 
Journal:  Cell       Date:  1993-12-31       Impact factor: 41.582

Review 6.  The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

Authors:  Jingxiang Huang; Brendan D Manning
Journal:  Biochem J       Date:  2008-06-01       Impact factor: 3.857

7.  Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Authors:  J Chen; X F Zheng; E J Brown; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-23       Impact factor: 11.205

8.  An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Authors:  Carson C Thoreen; Seong A Kang; Jae Won Chang; Qingsong Liu; Jianming Zhang; Yi Gao; Laurie J Reichling; Taebo Sim; David M Sabatini; Nathanael S Gray
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

9.  Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases.

Authors:  Tomohiko Matsuo; Yoshiya Kubo; Yoshinori Watanabe; Masayuki Yamamoto
Journal:  EMBO J       Date:  2003-06-16       Impact factor: 11.598

10.  A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.

Authors:  Akio Nakashima; Takahiro Hasegawa; Saori Mori; Masaru Ueno; Shigeyasu Tanaka; Takashi Ushimaru; Shusei Sato; Masahiro Uritani
Journal:  Curr Genet       Date:  2006-03-21       Impact factor: 2.695
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  8 in total

1.  Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats.

Authors:  Wanjun Qi; Maikel Acosta-Zaldivar; Peter R Flanagan; Ning-Ning Liu; Niketa Jani; José F Fierro; María T Andrés; Gary P Moran; Julia R Köhler
Journal:  PLoS Pathog       Date:  2022-06-10       Impact factor: 7.464

Review 2.  Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway.

Authors:  R Nicholas Laribee
Journal:  J Mol Biol       Date:  2018-10-23       Impact factor: 5.469

3.  Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by rapamycin in fission yeast.

Authors:  Kenichi Sajiki; Yuria Tahara; Alejandro Villar-Briones; Tomáš Pluskal; Takayuki Teruya; Ayaka Mori; Mitsuko Hatanaka; Masahiro Ebe; Takahiro Nakamura; Keita Aoki; Yukinobu Nakaseko; Mitsuhiro Yanagida
Journal:  Open Biol       Date:  2018-03       Impact factor: 6.411

Review 4.  Regulation of ribosomal protein genes: An ordered anarchy.

Authors:  Cyrielle Petibon; Mustafa Malik Ghulam; Mathieu Catala; Sherif Abou Elela
Journal:  Wiley Interdiscip Rev RNA       Date:  2020-10-10       Impact factor: 9.957

5.  The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.

Authors:  Isabel A Calvo; Shalini Sharma; Joao A Paulo; Alexander O D Gulka; Andras Boeszoermenyi; Jingyu Zhang; Jose M Lombana; Christina M Palmieri; Laura A Laviolette; Haribabu Arthanari; Othon Iliopoulos; Steven P Gygi; Mo Motamedi
Journal:  iScience       Date:  2021-10-23

6.  Pterocarpus marsupium extract extends replicative lifespan in budding yeast.

Authors:  Mitchell B Lee; Michael G Kiflezghi; Mitsuhiro Tsuchiya; Brian Wasko; Daniel T Carr; Priya A Uppal; Katherine A Grayden; Yordanos C Elala; Tu Anh Nguyen; Jesse Wang; Priya Ragosti; Sunny Nguyen; Yan Ting Zhao; Deborah Kim; Socheata Thon; Irika Sinha; Thao T Tang; Ngoc H B Tran; Thu H B Tran; Margarete D Moore; Mary Ann K Li; Karl Rodriguez; Daniel E L Promislow; Matt Kaeberlein
Journal:  Geroscience       Date:  2021-07-23       Impact factor: 7.713

7.  Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling.

Authors:  Nicholas Nelson; Geoffrey J Clark
Journal:  Oncotarget       Date:  2016-06-07

Review 8.  Structural Insights into TOR Signaling.

Authors:  Lucas Tafur; Jennifer Kefauver; Robbie Loewith
Journal:  Genes (Basel)       Date:  2020-08-04       Impact factor: 4.096
  8 in total

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